3-(羟基甲基)-2,2,5,5-四甲基-1-吡咯烷醇 | 27298-75-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 3-(羟基甲基)-2,2,5,5-四甲基-1-吡咯烷醇
• 中文别名: 3-(羟甲基)-2,2,5,5-四甲基吡咯烷-1-醇
• 英文名称: 3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolidin-1-ol
• 英文别名: (1-hydroxy-2,2,5,5-tetramethylpyrrolidin-3-yl)methanol
• CAS: 27298-75-5
• 化学式: C₉H₁₉NO₂
• 分子量: 173.25
• InChiKey: NVSLLEANKLJTSO-UHFFFAOYSA-N

物化性质

• 熔点：
  112-113°C

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• BIODEGRADABLE ORGANIC RADICAL-FUNCTIONALIZED POLYCARBONATES FOR MEDICAL APPLICATIONS
  申请人：International Business Machines Corporation

  公开号：US20160220705A1

  公开（公告）日：2016-08-04

  Paramagnetic, amphiphilic, biocompatible polymers were prepared comprising a carbonate repeat unit bearing a paramagnetic organic radical, more specifically a nitroxyl radical. The radical polymers can be produced in one step from a precursor polymer bearing an active ester side chain by treating the precursor polymer with a radical-bearing nucleophile. The precursor polymer can be prepared by organocatalyzed catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The radical polymers can be non-toxic and partially biodegradable. The radical polymers have utility as contrast enhancing agents in a medical imaging application and/or as therapeutic agents for treating a medical condition. The radical polymers can also serve as carriers for therapeutic agents (e.g., drugs) and/or medical image enhancing agents (e.g., NIRF dyes).

  具有顺磁性、两性亲疏性、生物相容性的聚合物已经制备好，其中包含一个带有顺磁性有机自由基的碳酸酯重复单元，更具体地说是一个亚硝基自由基。这种自由基聚合物可以通过将带有活性酯侧链的前体聚合物与带有自由基的亲核试剂处理而一步制备而成。前体聚合物可以通过有机催化的环氧化聚合（ROP）来制备，该环氧化单体带有活性酯侧链。这种自由基聚合物可能是无毒且部分可生物降解的。这种自由基聚合物在医学成像应用中可用作增强对比剂，和/或作为治疗医疗状况的治疗剂。这种自由基聚合物还可以作为治疗剂（例如药物）和/或医学图像增强剂（例如NIRF染料）的载体。
• Drug Resistance Reversal In Neoplastic Disease
  申请人：Patil Ghanshyam

  公开号：US20080200405A1

  公开（公告）日：2008-08-21

  The present invention is directed to compounds, compositions, and methods for halting or reversing the effects of chemoresistance in neoplastic diseases. In particular the use of hydroxylamines is described.

  本发明涉及用于阻止或逆转肿瘤性疾病化疗耐药效应的化合物、组合物和方法。具体描述了羟胺的使用。
• MITOCHONDRIA TARGETED CATIONIC ANTI-OXIDANT COMPOUNDS FOR PREVENTION, THERAPY OR TREATMENT OF HYPER-PROLIFERATIVE DISEASE, NEOPLASIAS AND CANCERS
  申请人：Zarling David A.

  公开号：US20110059922A1

  公开（公告）日：2011-03-10

  The inventions disclosed include methods of treating cancers and related neoplasias, especially prostate cancer, with pharmaceutically acceptable salts comprising lipophilic cation moieties linked to nitroxide or linked to hydroxylamine anti-oxidant groups.

  披露的发明包括使用含有脂溶性阳离子基团与亚硝酰基或羟胺抗氧化基团相连的药用盐来治疗癌症和相关的新生物病变，特别是前列腺癌的方法。
• Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders
  申请人：Haj-Yehia Ibrahim Abdullah

  公开号：US20050228184A1

  公开（公告）日：2005-10-13

  The present invention relates to multifunctional β-agonist compounds comprising a reactive oxygen species scavenger group and a nitric oxide donor, and their use for the treatment of respiratory diseases involving airway obstruction, such as asthma and chronic bronchitis. The invention further relates to methods and devices for administering the compounds.

  本发明涉及多功能β-激动剂化合物，包括具有反应性氧化物清除剂基团和一氧化氮供体，以及它们的用途，用于治疗涉及气道阻塞的呼吸系统疾病，如哮喘和慢性支气管炎。本发明还涉及用于给药这些化合物的方法和装置。
• Beta-blockers having antioxidant and no-donor activity
  申请人：Haj-Yehia I Abdullah

  公开号：US20060258652A1

  公开（公告）日：2006-11-16

  Multifunctional beta-antagonist compounds are provided, that combine β-adrenergic receptor blocking activity with capability to scavenge superoxide and other reactive oxygen species, and that may further function as nitric oxide donors. The compounds are useful for preventing or treating disorders in which the treatment with β-antagonists is indicated, or which are associated with oxidative stress.

  提供了多功能β-拮抗剂化合物，其将β-肾上腺素能受体阻滞活性与清除超氧化物和其他反应性氧化物的能力相结合，并可能进一步作为一氧化氮供体发挥作用。这些化合物可用于预防或治疗需要β-拮抗剂治疗或与氧化应激有关的疾病。