3-(羟基甲基)邻苯二酚 | 14235-77-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 3-(羟基甲基)邻苯二酚
• 英文名称: 2,3-dihydroxybenzyl alcohol
• 英文别名: 3-(Hydroxymethyl)pyrocatechol；3-(hydroxymethyl)benzene-1,2-diol
• CAS: 14235-77-9
• 化学式: C₇H₈O₃
• 分子量: 140.139
• InChiKey: UBFALTGHGHULNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2907299090

反应信息

• 作为反应物：
  描述：

  3,4-二甲氧基苯乙酸 、 3-(羟基甲基)邻苯二酚 在 bismuth(lll) trifluoromethanesulfonate 作用下， 以 硝基甲烷 为溶剂， 反应 15.0h， 以76%的产率得到4-hydroxy-9,10-dimethoxy-7,12-dihydro-5-oxadibenzo[a,d]cycloocten-6-one
  参考文献：
  名称：

  Bi(OTf)3-催化氧化芳基乙酸与水杨醇的环缩合反应。5-氧二苯并[a,d]环辛烯-6-酮的合成

  摘要：

  Bi(OTf) 3催化氧化芳基乙酸与水杨醇的一锅串联环缩合在回流的MeNO 2条件下以中等至良好的产率提供5-氧二苯并[ a , d ]环辛烯-6-酮。这里提出并讨论了一个合理的机制。在整个反应过程中，水是唯一产生的副产物。研究了各种金属三氟甲磺酸盐促进的反应条件以实现一锅高效 (4+4) 环化。

  DOI：

  10.1002/adsc.202200622
• 作为产物：
  描述：

  2,3-二羟基苯甲醛 在 甲醇 、 sodium tetrahydroborate 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以73%的产率得到3-(羟基甲基)邻苯二酚
  参考文献：
  名称：

  Bi(OTf)3-催化氧化芳基乙酸与水杨醇的环缩合反应。5-氧二苯并[a,d]环辛烯-6-酮的合成

  摘要：

  Bi(OTf) 3催化氧化芳基乙酸与水杨醇的一锅串联环缩合在回流的MeNO 2条件下以中等至良好的产率提供5-氧二苯并[ a , d ]环辛烯-6-酮。这里提出并讨论了一个合理的机制。在整个反应过程中，水是唯一产生的副产物。研究了各种金属三氟甲磺酸盐促进的反应条件以实现一锅高效 (4+4) 环化。

  DOI：

  10.1002/adsc.202200622

文献信息

• Ionene-Bound Borohydrides: Efficient, Selective, and Versatile Polymer-Supported Reducing Agents
  作者：Moslem M. Lakouraj、Mahmood Tajbakhsh、Majid S. Mahalli

  DOI：10.1007/s00706-007-0756-5

  日期：2008.2

  Reduction of structurally different carbonyl compounds, such as aldehydes, ketones, α,β-unsaturated enals and enones, acid chlorides, and imines was accomplished efficiently using high capacity ionene based borohydride reagents. Aldehydes and imines were reduced to the corresponding alcohols and amines in excellent yields in methanol at ambient temperature while ketones and acid chlorides were reduced

  使用高容量的基于紫罗烯的硼氢化物试剂可以有效地完成结构不同的羰基化合物的还原，例如醛，酮，α，β-不饱和烯和烯酮，酰氯和亚胺。在环境温度下，醛和亚胺在甲醇中以优异的产率还原为相应的醇和胺，而在 异丙醇 和 THF - Me OH中在回流下将酮和酰氯还原 。用这些试剂成功地实现了醛对酮的化学选择性还原。在α，β-不饱和醛和酮的还原中也观察到完全的区域选择性。
• Conformationally constrained compounds as dendrimer cores
  申请人：——

  公开号：US20030232932A1

  公开（公告）日：2003-12-18

  There are provided novel chemical compounds and their uses in the preparation of polymers and oligomers, and the preparation of such compounds. In certain embodiments there are provided dendritic polymers and oligomers, of a type having at least four polymeric or oligomeric organic chains emanating from a single chemical core, each of the chains being of substantially equal length and substantially the same chemical composition. Such compounds may be referred to as dendrimers. Also provided are novel chemical entities useful as core entities in the preparation of dentrimers. Dendrimers can recognize a core substructure to which the polymeric/oligomeric chains (“dendrons”) are covalenty attached and from which they extend with systematic branching radially outward in a three dimensional fashion, to approximately the same extent to each other. Together, core and dendrons constitute macromolecules possessing a high degree of internal structural replication attributable to the branches.

  提供了新颖的化合物以及它们在聚合物和寡聚物制备中的用途，以及这些化合物的制备方法。在某些实施例中，提供了树枝状聚合物和寡聚物，这种类型的聚合物或寡聚物具有至少四条聚合物或寡聚物有机链从单一化学核心中发出，每条链的长度基本相等且化学组成基本相同。这种化合物可以称为树状聚合物。还提供了作为核心实体在制备树状聚合物中有用的新颖化学实体。树状聚合物可以识别一个核心亚结构，聚合物/寡聚物链（“树状体”）以共价键连接并沿着径向向外以三维方式系统地分支延伸，使它们彼此的延伸程度大致相同。核心和树状体一起构成具有高度内部结构复制度的大分子，这种复制度归因于分支。
• [EN] COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS<br/>[FR] COMPOSÉS DESTINÉS AU TRAITEMENT DE TROUBLES MÉTABOLIQUES
  申请人：WELLSTAT THERAPEUTICS CORP

  公开号：WO2009091732A1

  公开（公告）日：2009-07-23

  Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. The agent is a compound of Formula (I): wherein m is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R1 is hydrogen or alkyl having from 1 to 3 carbon atoms; and R2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms. A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, hydroxy, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono- substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon; Alternatively, the agent can be a pharmaceutically acceptable salt of the compound of Formula (I).

  本发明涉及一种用于治疗各种代谢性疾病的药物，例如胰岛素抵抗综合征、糖尿病、多囊卵巢综合征、高脂血症、脂肪肝病、消瘦、肥胖症、动脉粥样硬化和动脉硬化。该药物是公式（I）的化合物：其中m为0、1、2、3、4、5、6、7或8；R1为氢或具有1至3个碳原子的烷基；R2为氢、卤素、具有1至3个碳原子的烷基或具有1至3个碳原子的烷氧基。A为苯基，未取代或被1或2个选自以下基团的基团取代：卤素、羟基、具有1或2个碳原子的烷基、全氟甲基、具有1或2个碳原子的烷氧基和全氟甲氧基；或具有3至6个环碳原子的环烷基，其中环烷基未取代或一个或两个环碳原子独立地被甲基或乙基单取代；或具有1或2个选自N、S和O的环杂原子的5或6元杂环芳基，且杂环芳基通过环碳原子与公式I的剩余部分共价结合。或者，该药物可以是公式（I）的药学上可接受的盐。
• Tri-peptide Inhibitors of Serine Elastases
  申请人：Cheronis John C.

  公开号：US20090156509A1

  公开（公告）日：2009-06-18

  The present invention provides compounds of formula (I): where X is R 1 —(CR 3 R 4 ) n OC(O)—; R 1 —(CR 3 R 4 ) n C(O)—; R 1 —C(O)NH(CR 3 R 4 ) n OC(O)—; R 1 —C(O)NH(CR 3 R 4 ) n C(O)—; R 1 —C(O)(CR 3 R 4 ) n OC(O)—; or R 1 —C(O)(CR 3 R 4 ) n C(O)—; where R 1 is optionally substituted C 5-10 aryl or heteroaryl; OH or NH 2 ; where R 3 and R 4 are independently H or methyl; and n is 0 to 6; and Y is —CF 3 or one of: where R 2 is C 1-8 alkyl optionally substituted with halo or —OH; —(CR 6 R 7 ) p —C 5-6 aryl optionally substituted with halo, —OH, C 1-8 alkyl, C 1-8 haloalkyl, —(CH 2 ) m C(O)NH 2 or —(CH 2 ) m OCH 3 ; where R 6 and R 7 are independently H or methyl; m is 0 to 4, and p is 0 or 1 or a pharmaceutically acceptable salt, ester, metabolite or prodrug thereof

  本发明提供了式(I)的化合物：其中X为R1—(CR3R4)nOC(O)—; R1—(CR3R4)nC(O)—; R1—C(O)NH(CR3R4)nOC(O)—; R1—C(O)NH(CR3R4)nC(O)—; R1—C(O)(CR3R4)nOC(O)—; 或R1—C(O)(CR3R4)nC(O)—;其中R1为可选择的取代C5-10芳基或杂环芳基; OH或NH2;其中R3和R4独立地为H或甲基; n为0到6;以及Y为—CF3或下列之一：其中R2为C1-8烷基，可选择地取代卤或—OH; —(CR6R7)p—C5-6芳基，可选择地取代卤，—OH，C1-8烷基，C1-8卤代烷基，—(CH2)mC(O)NH2或—(CH2)mOCH3;其中R6和R7独立地为H或甲基; m为0到4，p为0或1或其药学上可接受的盐，酯，代谢物或前药。
• Apparatus and process for generating mixed multi-component vapor
  申请人：Ube Industries, Ltd.

  公开号：US20020134517A1

  公开（公告）日：2002-09-26

  A mixed liquid of two or more components different in boiling temperature from each other and soluble in or compatible with each other is evaporated into a mixed vapor having a similar composition to that of the mixed liquid by using an apparatus having a thin film evaporator ( 1 ) having a feed inlet ( 1 a ) and a delivery outlet ( 1 b ), while forcedly circulating the non-evaporated portion of the mixed multi-component liquid by withdrawing the non-evaporated mixed liquid portion from the delivery side end portion of the evaporator and returning the mixed liquid portion into the feed side end portion of the evaporator through a circulating line ( 3 ), and the resultant mixed multi-component vapor can be used as a mixed material vapor for a gas phase catalytic reaction for producing, for example, a mono and/or a di-alkylether of an aromatic dihydroxy compound.

  通过使用具有薄膜蒸发器（1）的装置，将两个或多个沸点不同且可溶于或相容的组分的混合液蒸发成具有类似于混合液的组成的混合气体，同时通过从蒸发器的输送端口（1b）提取未蒸发的混合多组分液体并通过循环管道（3）将混合液体返回到蒸发器的进料端口（1a），强制循环混合多组分液体的未蒸发部分，得到的混合多组分蒸汽可用作气相催化反应的混合材料蒸汽，例如用于生产芳香族二羟化合物的单烷基和/或双烷基醚。