3-(萘-2-基硫烷基)-庚酸 | 1027834-93-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 3-(萘-2-基硫烷基)-庚酸
• 英文名称: 3-(Naphthalen-2-ylsulfanyl)-heptanoic acid
• 英文别名: 3-Naphthalen-2-ylsulfanylheptanoic acid
• CAS: 1027834-93-0
• 化学式: C₁₇H₂₀O₂S
• 分子量: 288.411
• InChiKey: OVQYWZOCDMKGMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(萘-2-基硫烷基)-庚酸 在 2-(Phenylsulfonyl)-3-phenyloxaziridin 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 N-[tert-butyl(dimethyl)silyl]oxy-3-naphthalen-2-ylsulfinylheptanamide
  参考文献：
  名称：

  Hydroxamic Acid Derivatives as Potent Peptide Deformylase Inhibitors and Antibacterial Agents

  摘要：

  Low-molecular-weight beta-sulfonyl- and beta-sulfinylhydroxamic acid derivatives have been synthesized and found to be potent inhibitors of Escherichia coli peptide deformylase (PDF). Most of the compounds synthesized and tested displayed antibacterial activities that cover several pathogens found in respiratory tract infections, including Chlamydia pneumoniae, Mycoplasma pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The potential of these compounds as antibacterial agents is discussed with respect to selectivity, intracellular concentrations in bacteria, and potential for resistance development.

  DOI：

  10.1021/jm000018k
• 作为产物：
  描述：

  反-2-庚烯酸 、 2-萘硫醇 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 生成 3-(萘-2-基硫烷基)-庚酸
  参考文献：
  名称：

  Hydroxamic Acid Derivatives as Potent Peptide Deformylase Inhibitors and Antibacterial Agents

  摘要：

  Low-molecular-weight beta-sulfonyl- and beta-sulfinylhydroxamic acid derivatives have been synthesized and found to be potent inhibitors of Escherichia coli peptide deformylase (PDF). Most of the compounds synthesized and tested displayed antibacterial activities that cover several pathogens found in respiratory tract infections, including Chlamydia pneumoniae, Mycoplasma pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The potential of these compounds as antibacterial agents is discussed with respect to selectivity, intracellular concentrations in bacteria, and potential for resistance development.

  DOI：

  10.1021/jm000018k

文献信息

• Hydroxamic Acid Derivatives as Potent Peptide Deformylase Inhibitors and Antibacterial Agents
  作者：Christian Apfel、David W. Banner、Daniel Bur、Michel Dietz、Takahiro Hirata、Christian Hubschwerlen、Hans Locher、Malcolm G. P. Page、Wolfgang Pirson、Gérard Rossé、Jean-Luc Specklin

  DOI：10.1021/jm000018k

  日期：2000.6.1

  Low-molecular-weight beta-sulfonyl- and beta-sulfinylhydroxamic acid derivatives have been synthesized and found to be potent inhibitors of Escherichia coli peptide deformylase (PDF). Most of the compounds synthesized and tested displayed antibacterial activities that cover several pathogens found in respiratory tract infections, including Chlamydia pneumoniae, Mycoplasma pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The potential of these compounds as antibacterial agents is discussed with respect to selectivity, intracellular concentrations in bacteria, and potential for resistance development.