<1-(Ethoxycarbonyl)-6-carboxy-2-oxohexylidene>triphenylphopshorane | 128925-56-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: <1-(Ethoxycarbonyl)-6-carboxy-2-oxohexylidene>triphenylphopshorane
• 英文别名: 7-ethoxycarbonyl-6-oxo-7-(triphenylphosphoranylidene)heptanoic acid；8-Ethoxy-6,8-dioxo-7-(triphenyl-lambda5-phosphanylidene)octanoic acid；8-ethoxy-6,8-dioxo-7-(triphenyl-λ5-phosphanylidene)octanoic acid
• CAS: 128925-56-4
• 化学式: C₂₈H₂₉O₅P
• 分子量: 476.509
• InChiKey: FCOKKZOHMBCDPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  34
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  <1-(Ethoxycarbonyl)-6-carboxy-2-oxohexylidene>triphenylphopshorane 以34%的产率得到
  参考文献：
  名称：

  Abell Andrew D., Hoult Deborah A., Morris Kathy M., Taylor Jane M., Trent+, J. Org. Chem., 58 (1993) N 6, S 1531-1537

  摘要：

  DOI：
• 作为产物：
  描述：

  乙氧甲酰基亚甲基三苯基膦 、 己二酸酐 以 二氯甲烷 为溶剂， 反应 18.0h， 以29%的产率得到<1-(Ethoxycarbonyl)-6-carboxy-2-oxohexylidene>triphenylphopshorane
  参考文献：
  名称：

  Synthesis and deprotection of [1-(ethoxycarbonyl)-4-[(diphenylmethoxy)carbonyl]-1-methyl-2-oxobutyl]triphenylphosphonium chloride: a key intermediate in the Wittig reaction between a cyclic anhydride and a stabilized ylide

  摘要：

  DOI：

  10.1021/jo00305a013

文献信息

• Halogenation of keto acid phosphoranes: synthesis of halo enol lactones and haloallenes
  作者：Andrew D. Abell、Deborah A. Hoult、Kathy M. Morris、Jane M. Taylor、John O. Trent

  DOI：10.1021/jo00058a039

  日期：1993.3

  Halolactonization of the keto acid phosphoranes 6a-f, 40, and 41 takes place with either Br2 or SO2Cl2 and Et3N to give the E- and Z-halo enol lactones 10-15, 42, and 43 in good yields. The cyclization proceeds via a halo phosphonium salt, e.g. 19. Halo phosphonium salts yield a halo allene when cyclization is not favoured as in the formation of the bromoallenes 24 and 37. The configuration of the halo enol lactones was determined by H-1 and C-13 NMR spectroscopy and via single-crystal X-ray determinations on 11a, 14c, and 42b. The barrier to interconversion of the biphenyl conformations of the bromo enol lactones 42b and 43b was determined by H-1 NMR spectroscopy at elevated temperatures.
• ABELL, ANDREW D.;MORRIS, KATHRYN B.;LITTEN, J. CHRISTOPHER, J. ORG. CHEM., 55,(1990) N8, C. 5217-5221
  作者：ABELL, ANDREW D.、MORRIS, KATHRYN B.、LITTEN, J. CHRISTOPHER

  DOI：——

  日期：——
• Abell Andrew D., Hoult Deborah A., Morris Kathy M., Taylor Jane M., Trent+, J. Org. Chem., 58 (1993) N 6, S 1531-1537
  作者：Abell Andrew D., Hoult Deborah A., Morris Kathy M., Taylor Jane M., Trent+

  DOI：——

  日期：——
• Synthesis and deprotection of [1-(ethoxycarbonyl)-4-[(diphenylmethoxy)carbonyl]-1-methyl-2-oxobutyl]triphenylphosphonium chloride: a key intermediate in the Wittig reaction between a cyclic anhydride and a stabilized ylide
  作者：Andrew D. Abell、Kathryn B. Morris、J. Christopher Litten

  DOI：10.1021/jo00305a013

  日期：1990.8