Thiourea, N-[(2-fluoro-3-methylphenyl)methyl]-N'-(2-hydroxyethyl)- | 629628-15-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Thiourea, N-[(2-fluoro-3-methylphenyl)methyl]-N'-(2-hydroxyethyl)-
• 英文别名: 1-[(2-fluoro-3-methylphenyl)methyl]-3-(2-hydroxyethyl)thiourea
• CAS: 629628-15-5
• 化学式: C₁₁H₁₅FN₂OS
• 分子量: 242.32
• InChiKey: CFBRBALWOOZLTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  76.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Novel methods and compositions for alleviating pain
  申请人：Allergan, Inc.

  公开号：EP2351561A2

  公开（公告）日：2011-08-03

  The present invention provides a method for the long-term relief of chronic pain in a subject by activating in the subject an analgesic alpha-adrenergic receptor in the absence of alpha-2A receptor activation over a period of at least three days, such that relief of chronic pain is maintained in the absence of continued activation of said receptor. The analgesic alpha-adrenergic receptor can be, for example, the alpha-2B receptor.

  本发明提供了一种长期缓解受试者慢性疼痛的方法，在α-2A受体未被激活的情况下，激活受试者体内的镇痛剂α-肾上腺素能受体至少三天，从而在所述受体未被持续激活的情况下保持慢性疼痛的缓解。镇痛的α-肾上腺素能受体可以是α-2B受体等。
• METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS
  申请人：ALLERGAN, INC.

  公开号：EP3332782A1

  公开（公告）日：2018-06-13

  Disclosed herein is a method of upregulating regulatory T-cells, and treating diseases that would benefit from such upregulation, by administering an alpha 2 receptor agonist.

  本文公开了一种通过施用α2 受体激动剂来上调调节性 T 细胞并治疗可从这种上调中获益的疾病的方法。
• ALPHA-2B RECEPTOR AGONIST AND 5HT4 SEROTONIN RECEPTOR COMPOSITIONS FOR TREATING GASTROINTESTINAL MOTILITY DISORDERS
  申请人：Brooks Gregory F.

  公开号：US20080153825A1

  公开（公告）日：2008-06-26

  Disclosed herein is a pharmaceutical composition comprising a 5-HT4 serotonin receptor agonist and an alpha-2B receptor agonist. The composition is effective for treating gastrointestinal motility disorders, and methods of treating such disorders using the composition and compounds comprising it are also disclosed.
• ALPHA-2B RECEPTOR AGONIST AND ANTICONVULSANT COMPOSITIONS FOR TREATING CHRONIC PAIN
  申请人：Gil Daniel W.

  公开号：US20080153874A1

  公开（公告）日：2008-06-26

  Disclosed herein is a pharmaceutical composition comprising a pain-relieving anticonvulsant and an alpha-2B receptor agonist. The composition is effective for treating chronic pain, and methods of treating chronic pain using the composition and the compounds comprising it are also disclosed.
• ALPHA-2B RECEPTOR AGONIST AND ACID REDUCER COMPOSITIONS FOR TREATING GASTROINTESTINAL MOTILITY DISORDERS
  申请人：Brooks Gregory F.

  公开号：US20080153881A1

  公开（公告）日：2008-06-26

  Disclosed herein is a pharmaceutical composition comprising an acid reducer and an alpha-2B receptor agonist. The composition is effective for treating gastrointestinal motility disorders, and methods of treating such disorders using the composition and compounds comprising it are also disclosed.