[(2R,3S,5R)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-yl]oxy-methylphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-methylphosphoryl]oxymethyl]-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl] acetate | 188944-89-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: [(2R,3S,5R)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-yl]oxy-methylphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-methylphosphoryl]oxymethyl]-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl] acetate
• CAS: 188944-89-0
• 化学式: C₄₄H₅₄N₁₀O₁₈P₂
• 分子量: 1072.92
• InChiKey: AHCGRXAXJBBVJC-WQXYNXAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  74
• 可旋转键数：
  20
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  345
• 氢给体数：
  5
• 氢受体数：
  20

反应信息

• 作为反应物：
  描述：

  (S_P)-5'-O-dimethoxytrityl-N⁴-benzoylcytidine 3'-O-(Se-methyl methanephosphonoselenolate) 、 [(2R,3S,5R)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-yl]oxy-methylphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-methylphosphoryl]oxymethyl]-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl] acetate 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 lithium chloride 作用下， 以 吡啶 为溶剂， 生成 [(2R,3S,5R)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[[(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl]oxy-methylphosphoryl]oxymethyl]oxolan-3-yl]oxy-methylphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-methylphosphoryl]oxymethyl]-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl] acetate
  参考文献：
  名称：

  New Stereospecific Method of Synthesis of [Sp]- and [Rp]-Dinucleoside-(3',5') Methanephosphonates

  摘要：

  Using a stereoretentive reaction between diastereomerically pure 5'-O-DMT-(N-protected) nucleoside 3'-O-(Se-methyl methanephosphonoselenolate)s and 3'-O-acetyl-(N-protected) nucleosides, diastereomerically pure dinucleoside-(3',5') methanephosphonates as well as ''all-Rp'' and ''all-Sp'' trimers, tetramers, and pentamers were synthesized.

  DOI：

  10.1021/jo00099a001
• 作为产物：
  描述：

  3'-O-acetyl-N2-isobutyryl-2'-deoxyguanosine 在 溶剂黄146 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 lithium chloride 作用下， 以 吡啶 为溶剂， 生成 [(2R,3S,5R)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-yl]oxy-methylphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-methylphosphoryl]oxymethyl]-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl] acetate
  参考文献：
  名称：

  New Stereospecific Method of Synthesis of [Sp]- and [Rp]-Dinucleoside-(3',5') Methanephosphonates

  摘要：

  Using a stereoretentive reaction between diastereomerically pure 5'-O-DMT-(N-protected) nucleoside 3'-O-(Se-methyl methanephosphonoselenolate)s and 3'-O-acetyl-(N-protected) nucleosides, diastereomerically pure dinucleoside-(3',5') methanephosphonates as well as ''all-Rp'' and ''all-Sp'' trimers, tetramers, and pentamers were synthesized.

  DOI：

  10.1021/jo00099a001

文献信息

• New Stereospecific Method of Synthesis of [Sp]- and [Rp]-Dinucleoside-(3',5') Methanephosphonates
  作者：Lucyna A. Wozniak、Jaroslaw Pyzowski、Michal Wieczorek、Wojciech J. Stec

  DOI：10.1021/jo00099a001

  日期：1994.10

  Using a stereoretentive reaction between diastereomerically pure 5'-O-DMT-(N-protected) nucleoside 3'-O-(Se-methyl methanephosphonoselenolate)s and 3'-O-acetyl-(N-protected) nucleosides, diastereomerically pure dinucleoside-(3',5') methanephosphonates as well as ''all-Rp'' and ''all-Sp'' trimers, tetramers, and pentamers were synthesized.