3-amino-5-(3,4-dimethoxy-phenyl)-1,5-dihydro-pyrazolo[4,3-c]pyridazin-6-one | 746647-47-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-amino-5-(3,4-dimethoxy-phenyl)-1,5-dihydro-pyrazolo[4,3-c]pyridazin-6-one
• 英文别名: 3-amino-5-(3,4-dimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridazin-6-one
• CAS: 746647-47-2
• 化学式: C₁₃H₁₃N₅O₃
• 分子量: 287.278
• InChiKey: GWLYEOUNIOYSDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-chloro-1-(3,4-dimethoxy-phenyl)-6-oxo-1,6-dihydro-pyridazine-3-carbonitrile 在 肼 作用下， 以 乙醇 为溶剂， 反应 18.0h， 生成 3-amino-5-(3,4-dimethoxy-phenyl)-1,5-dihydro-pyrazolo[4,3-c]pyridazin-6-one
  参考文献：
  名称：

  [EN] PYRAZOLOPYRIDAZINES USEFUL AS INHIBITORS OF PROTEIN KINASES
  [FR] COMPOSITIONS UTILES EN TANT QU'INHIBITEURS DE PROTEINE KINASES

  摘要：

  公开号：

  WO2004072029A3

文献信息

• Compositions useful as inhibitors of protein kinases
  申请人：——

  公开号：US20040192682A1

  公开（公告）日：2004-09-30

  The present invention provides a compound of formula I: 1 or a pharmaceutically acceptable salt or mixtures thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK mammalian protein kinase, and more particularly inhibitors of GSK-3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

  本发明提供一种I式化合物：1或其药学上可接受的盐或混合物。这些化合物是蛋白激酶的抑制剂，特别是哺乳动物GSK蛋白激酶的抑制剂，更具体地是GSK-3哺乳动物蛋白激酶的抑制剂。本发明还提供了包含本发明化合物的药学上可接受的组合物，以及利用这些化合物和组合物治疗各种蛋白激酶介导的疾病的方法。
• Compositions Useful as Inhibitors of Protein Kinases
  申请人：Green Jeremy

  公开号：US20090325968A1

  公开（公告）日：2009-12-31

  The present invention provides a compound of formula I: or a pharmaceutically acceptable salt or mixtures thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK mammalian protein kinase, and more particularly inhibitors of GSK-3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.

  本发明提供了公式I的化合物：或其药学上可接受的盐或混合物。这些化合物是蛋白激酶的抑制剂，特别是GSK哺乳动物蛋白激酶的抑制剂，更特别是GSK-3哺乳动物蛋白激酶的抑制剂。本发明还提供了包括本发明化合物的药学上可接受的组合物以及利用这些化合物和组合物治疗各种蛋白激酶介导的疾病的方法。
• US7601718B2
  申请人：——

  公开号：US7601718B2

  公开（公告）日：2009-10-13
• US8653088B2
  申请人：——

  公开号：US8653088B2

  公开（公告）日：2014-02-18
• [EN] COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES<br/>[FR] COMPOSITIONS UTILES EN TANT QU'INHIBITEURS DE PROTEINE KINASES
  申请人：VERTEX PHARMA

  公开号：WO2004072029A2

  公开（公告）日：2004-08-26

  The present invention provides a compound of formula I: or a pharmaceutically acceptable salt or mixtures thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK mammalian protein kinase, and more particularly inhibitors of GSK-3 mammalian protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.