toltrazuril sulfoxide | 146426-24-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: toltrazuril sulfoxide
• 英文别名: 1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfinyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione
• CAS: 146426-24-6
• 化学式: C₁₈H₁₄F₃N₃O₅S
• 分子量: 441.387
• InChiKey: QWKYIPKCLAUFCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• TRIAZINETRIONE DERIVATIVES AND THEIR USE AS MODULATORS OF NEUROTROPHIN RECEPTOR AND RECEPTOR TYROSINE KINASES
  申请人：ALZECURE PHARMA AB

  公开号：US20200113910A1

  公开（公告）日：2020-04-16

  The present invention relates to anew use of 4-phenoxy-phenyl-1,3,5-triazine derivatives or pharmaceutically acceptable salts thereof, according to formula I, wherein R 1 , R 2 and U have meanings as provided in the description, as medicaments for the treatment and/or prevention of diseases characterised by impaired signalling of neurotrophins and/or other trophic factors. In particular, the invention relates to the treatment of such diseases in patients with the Val66Met mutation in the brain-derived neurotrophic factor gene.
• US4219552A
  申请人：——

  公开号：US4219552A

  公开（公告）日：1980-08-26