4-({[({[4-(3,4-Dichlorobenzyl)Morpholin-2-yl]Methyl}Amino)Carbonyl]Amino}Methyl)Benzamide | 408303-42-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-({[({[4-(3,4-Dichlorobenzyl)Morpholin-2-yl]Methyl}Amino)Carbonyl]Amino}Methyl)Benzamide
• 英文别名: 4-{3-[4-(3,4-Dichloro-benzyl)-morpholin-2-ylmethyl]-ureidomethyl}-benzamide；4-[[[4-[(3,4-dichlorophenyl)methyl]morpholin-2-yl]methylcarbamoylamino]methyl]benzamide
• CAS: 408303-42-4
• 化学式: C₂₁H₂₄Cl₂N₄O₃
• 分子量: 451.353
• InChiKey: GPLUUMAKBFSDIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  96.7
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] CRTH2 RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RECEPTEUR DE CRTH2
  申请人：NOVARTIS AG

  公开号：WO2005105727A1

  公开（公告）日：2005-11-10

  There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R3, X, Y, Z, m, and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.

  根据该发明提供了化合物的公式(I)的自由或盐形式，其中R1、R2、R3、X、Y、Z、m和n如规范中所述，以及制备它们的过程，以及它们作为药物的用途。
• Compounds useful in the treatment of inflammatory diseases
  申请人：——

  公开号：US20040058907A1

  公开（公告）日：2004-03-25

  There are provided according to the invention, novel compounds of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X a, b, and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

  根据本发明提供了新颖的化合物公式（I），其中R1、R2、R3、R4、R5、R6、X、a、b和Z如规范中所定义，制备它们的方法，包含它们的配方以及它们在治疗炎症性疾病方面的应用。
• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSES ORGANIQUES
  申请人：NOVARTIS AG

  公开号：WO2005123731A2

  公开（公告）日：2005-12-29

  There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.

  根据本发明提供了公式（I）的化合物，以自由形式或盐形式提供，其中R1、R2、R3、R4、R5、R6、Q、W、X、m、n和p如规范中所述，以及制备它们的过程，和它们作为药物的用途。
• Organic Compounds For the Treatment of Inflammatory or Allergic Conditions
  申请人：Axford Jake

  公开号：US20080200466A1

  公开（公告）日：2008-08-21

  Compounds of formula (I) in free or pharmaceutically acceptable salt form, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , m, n, w, X, and Y have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh 2 receptor, especially inflammatory or obstructive airways diseases.

  式(I)的化合物，其自由形式或药学上可接受的盐形式，其中R1、R2、R3、R4、R5、R6、R7、m、n、w、X和Y的含义如规范所示，可用于治疗由CRTh2受体介导的疾病，特别是炎症性或阻塞性呼吸道疾病。
• Organic Compounds
  申请人：Sandham David Andrew

  公开号：US20090221578A1

  公开（公告）日：2009-09-03

  There are provided according to the invention compounds of formula (I) in free or salt form, wherein R 1 , R 2 , R 4 , R 5 , R 6 , D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.

  根据本发明提供了式（I）的化合物，其以自由形式或盐形式存在，其中R1、R2、R4、R5、R6、D、X、W、m和n如规范中所述，以及其制备过程和作为药物的用途。