2-Pyrrolidinone, 3-dodecyl-1-propyl- | 128345-85-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-Pyrrolidinone, 3-dodecyl-1-propyl-
• 英文别名: 3-dodecyl-1-propylpyrrolidin-2-one
• CAS: 128345-85-7
• 化学式: C₁₉H₃₇NO
• 分子量: 295.5
• InChiKey: QFKWRKMYLBDRDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  21
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-丙基-2-吡咯烷酮 、 溴代十二烷 生成 2-Pyrrolidinone, 3-dodecyl-1-propyl-
  参考文献：
  名称：

  MATSUI, KIEXIDEH;AOYANAGI, TAKAO;SUDZUKI, NANAMI;YAMAMURA, MARIKO

  摘要：

  DOI：

文献信息

• MATSUI, KIEXIDEH;AOYANAGI, TAKAO;SUDZUKI, NANAMI;YAMAMURA, MARIKO
  作者：MATSUI, KIEXIDEH、AOYANAGI, TAKAO、SUDZUKI, NANAMI、YAMAMURA, MARIKO

  DOI：——

  日期：——
• TRANSDERMAL HORMONE SPRAY
  申请人：Levinson R. Saul

  公开号：US20090075963A1

  公开（公告）日：2009-03-19

  The present invention provides a transdermal spray drug delivery system which comprises: a therapeutically effective amount of a hormone; at least one dermal penetration enhancer; and at least one volatile liquid. The invention also provides a method for administering at least one systemic acting hormone which comprises applying an effective amount of the hormone in the form of the drug delivery system of the present invention.
• TRANSDERMAL, ALCOHOL-FREE, PHARMACEUTICAL COMPOSITIONS
  申请人：Vacca Rita Downard

  公开号：US20090098069A1

  公开（公告）日：2009-04-16

  An alcohol-free, transdermal drug delivery composition administered via a metered spray drug delivery device is described herein. The non-occlusive transdermal drug delivery composition includes a therapeutically effective amount of at least one physiologically active agent or prodrug thereof, an effective amount of at least one dermal penetration enhancer; and at least one non-volatile liquid. The transdermal drug delivery composition is administered to a dermal or mucosal surface of an animal needing the same using a metered spray device capable of delivering a fine spray of substantially uniform particle size to minimize the required drying time therefor.
• MOLECULES AND CHIMERIC MOLECULES THEREOF
  申请人：Priest John D.

  公开号：US20090232808A1

  公开（公告）日：2009-09-17

  The present invention relates generally to the fields of proteins, diagnostics, therapeutics and nutrition. More particularly, the present invention provides an isolated protein molecule in or related to the tumour necrosis factor (TNF) superfamily such as TNF-a, Lymphotoxin-a (LT-a), TNFRI, TNFRII, OX40, BAFF, NGFR, Fas Ligand or chimeric molecules thereof comprising at least a portion of the protein molecule, such as TNF-a-Fc, LT-a-Fc, TNFRI-Fc, TNFRII-Fc, OX40-Fc, BAFF-Fc, NGFR-Fc, Fas Ligand-Fc; wherein the protein or chimeric molecule thereof has a profile of measurable physiochemical parameters, wherein the profile is indicative of, associated with or forms the basis of one or more pharmacological traits. The present invention further contemplates the use of the isolated protein or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications.
• Minoxidil Adjuvant Therapies
  申请人：Applied Biology, Inc.

  公开号：US20200214958A1

  公开（公告）日：2020-07-09

  Compositions and methods are disclosed herein for inducing (up-regulating) the expression of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXR-NR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells. In addition, compositions and methods for increasing or decreasing the growth rate of hair follicles is disclosed by altering the intracellular pH.