1-(4-Chloro-phenyl)-3-[2-(4-fluoro-3-methyl-phenylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea | 352326-82-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-Chloro-phenyl)-3-[2-(4-fluoro-3-methyl-phenylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea
• 英文别名: 1-(4-Chlorophenyl)-3-[2-(4-fluoro-3-methylanilino)pyrido[2,3-d]pyrimidin-7-yl]urea
• CAS: 352326-82-0
• 化学式: C₂₁H₁₆ClFN₆O
• 分子量: 422.849
• InChiKey: OHOPJOZAUWXPDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  91.8
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
  申请人：——

  公开号：US20030073668A1

  公开（公告）日：2003-04-17

  Disclosed are compounds of the formula (I) wherein: R 2 , R 7 , RI 3 , R 14 and R 15 are independently hydrogen, or (un)substituted lower alkyl, (un)substitued lower alkenyl, (un)substituted lower alkynyl, or (un)substituted —(CH 2 ) n R 12 ; R 5 is halogen, cyano, nitro, —R 9 , —NR 9 R 10 , or —OR 9 ; R 6 is halogen, cyano, nitro, —R 9 , —NR 9 R 10 , —OR 9 , —Co 2 R 9 , —COR 9 , —CONR 9 R 10 , —NR 9 COR 10 , (un)substiuted lower alkenyl, or (un)substituted lower alkynyl; R 8 is —CO 2 R 13 , —COR 13 , —CONR 13 R 14 , —CSNR 13 R 14 , —C(NR 13 )NR 14 R 15 , —SO 3 R 13 , —SO 2 R 13 , —SO 2 NR 13 R 14 , —PO 3 R 13 R 14 , —POR 13 R 14 , —PO(NR 13 R 14 ) 2 ; R 9 and R 10 are independently hydrogen or (un)substituted lower alkyl; R 11 is a heteroaryl or a heterocyclic group; R 12 is a cycloalkyl, a heterocyclic, an aryl, or a heteroaryl group; and n is 0,1,2, or 3. These compounds and their pharmaceutical compositions are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cdks and growth factor-mediated kinases.

  披露了公式(I)的化合物，其中：R2、R7、R13、R14和R15独立为氢，或（未）取代的低烷基，（未）取代的低烯基，（未）取代的低炔基，或（未）取代的—(CH2)nR12；R5为卤素，氰基，硝基，—R9，—NR9R10，或—OR9；R6为卤素，氰基，硝基，—R9，—NR9R10，—OR9，—Co2R9，—COR9，—CONR9R10，—NR9COR10，（未）取代的低烯基，或（未）取代的低炔基；R8为—CO2R13，—COR13，—CONR13R14，—CSNR13R14，—C(NR13)NR14R15，—SO3R13，—SO2R13，—SO2NR13R14，—PO3R13R14，—POR13R14，—PO(NR13R14)2；R9和R10独立为氢或（未）取代的低烷基；R11为杂芳基或杂环基团；R12为环烷基，杂环，芳基，或杂芳基团；n为0,1,2,或3。这些化合物及其药物组合物可用于治疗细胞增殖障碍，如癌症和再狭窄。这些化合物是cdks和生长因子介导激酶的强效抑制剂。
• PYRIDO 2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1254137A1

  公开（公告）日：2002-11-06
• US7053070B2
  申请人：——

  公开号：US7053070B2

  公开（公告）日：2006-05-30
• [EN] PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE PYRIDO[2,3-D]PYRIMIDINE-2,7-DIAMINE KINASE
  申请人：WARNER LAMBERT CO

  公开号：WO2001055147A1

  公开（公告）日：2001-08-02

  Disclosed are compounds of the formula (I) wherein: R?2, R7, R13, R14¿ and R¿15? are independently hydrogen, or (un)substituted lower alkyl, (un)substitued lower alkenyl, (un)substituted lower alkynyl, or (un)substituted -(CH2)nR?12; R5¿ is halogen, cyano, nitro, -R?9, -NR9R10¿, or -OR9; R6 is halogen, cyano, nitro, -R?9, -NR9R10, -OR9, -Co¿2R?9, -COR9, -CONR9R10, -NR9COR10¿, (un)substituted lower alkenyl, or (un)substituted lower alkynyl; R8 is -CO¿2?R?13, -COR13, -CONR13R14, -CSNR13R14, -C(NR13)NR14R15, -SO¿3R13, -S02R13, -SO2NR?13R14, -PO¿3R?13R14, -POR13R14¿, -PO(NR13R14)2; R?9 and R10¿ are independently hydrogen or (un)substituted lower alkyl; R11 is a heteroaryl or a heterocyclic group; R12 is a cycloalkyl, a heterocyclic, an aryl, or a heteroaryl group; and n is 0,1,2, or 3. These compounds and their pharmaceutical compositions are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cdks and growth factor-mediated kinases.