antimycin A_7a | 197791-88-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: antimycin A_7a
• 英文别名: urauchimycin B；Antimycin A7a；[(2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)amino]-2,6-dimethyl-8-(3-methylbutyl)-4,9-dioxo-1,5-dioxonan-7-yl] 2-methylpropanoate
• CAS: 197791-88-1
• 化学式: C₂₆H₃₆N₂O₉
• 分子量: 520.58
• InChiKey: ZFUIXKUZSFLVKA-GNEWFCMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  157
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  urauchimycin B 、 Isobutyryl-N-acetylcysteamine-thioester 在 5,5'-二硫双(2-硝基苯甲酸) 、 Streptomyces albus J₁₀₇₄ AntB 作用下， 反应 12.0h， 生成 antimycin A_7a
  参考文献：
  名称：

  Characterization of AntB, a Promiscuous Acyltransferase Involved in Antimycin Biosynthesis

  摘要：

  The in vivo and in vitro characterization of AntB, a dedicated acyltransferase encoded in the antimycin biosynthetic gene cluster, which catalyzes the C-8 acyloxy formation is reported. It is demonstrated that AntB has broad substrate specificity toward both the acyl substrate and the acyl carrier and produces more antimycin analogues with varying C-8 acyloxy moieties.

  DOI：

  10.1021/ol4014365

文献信息

• Characterization of AntB, a Promiscuous Acyltransferase Involved in Antimycin Biosynthesis
  作者：Moriah Sandy、Xuejun Zhu、Zhe Rui、Wenjun Zhang

  DOI：10.1021/ol4014365

  日期：2013.7.5

  The in vivo and in vitro characterization of AntB, a dedicated acyltransferase encoded in the antimycin biosynthetic gene cluster, which catalyzes the C-8 acyloxy formation is reported. It is demonstrated that AntB has broad substrate specificity toward both the acyl substrate and the acyl carrier and produces more antimycin analogues with varying C-8 acyloxy moieties.