(4R,5S)-4-methyl-5-phenyl-2-(phenylsulfanylmethyl)-4,5-dihydro-1,3-oxazole | 144397-24-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (4R,5S)-4-methyl-5-phenyl-2-(phenylsulfanylmethyl)-4,5-dihydro-1,3-oxazole
• CAS: 144397-24-0
• 化学式: C₁₇H₁₇NOS
• 分子量: 283.394
• InChiKey: VYZGQVWSJASXHN-CXAGYDPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  46.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯基腈乙基硫醚 在 盐酸 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 19.0h， 生成 (4R,5S)-4-methyl-5-phenyl-2-(phenylsulfanylmethyl)-4,5-dihydro-1,3-oxazole
  参考文献：
  名称：

  Preparation of Functionalized Oxazolines

  摘要：

  The preparation of several oxazolines substituted at C-2 by an hetero substituted methyl group is reported. 2-Aminomethyl, 2-azidomethyl, 2-nitromethyl and 2-hydroxymethyl oxazolines were obtained by substitution of the corresponding 2-halogenomethyl oxazolines. On the other hand, 2-benzyloxycarbonylaminomethyl, 2-thiophenylmethyl, 2-selenophenylmethyl oxazolines were prepared by condensation of the appropriate iminoether with a beta-aminoalcohol.

  DOI：

  10.1080/00397919208021650

文献信息

• Preparation of Functionalized Oxazolines
  作者：P. Breton、C. André-Barrès、Y. Langlois

  DOI：10.1080/00397919208021650

  日期：1992.9

  The preparation of several oxazolines substituted at C-2 by an hetero substituted methyl group is reported. 2-Aminomethyl, 2-azidomethyl, 2-nitromethyl and 2-hydroxymethyl oxazolines were obtained by substitution of the corresponding 2-halogenomethyl oxazolines. On the other hand, 2-benzyloxycarbonylaminomethyl, 2-thiophenylmethyl, 2-selenophenylmethyl oxazolines were prepared by condensation of the appropriate iminoether with a beta-aminoalcohol.