2-(2-(4-phenoxy-2-propylphenoxy)ethyl)indole-5-acetic acid | 209808-51-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-(4-phenoxy-2-propylphenoxy)ethyl)indole-5-acetic acid
• 英文别名: 2-[2-[2-(4-phenoxy-2-propylphenoxy)ethyl]-1H-indol-5-yl]acetic acid
• CAS: 209808-51-5
• 化学式: C₂₇H₂₇NO₄
• 分子量: 429.516
• InChiKey: DFFOSEJNFZUOSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  71.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Method for treating inflammatory diseases by administering a ppar-delta agonist
  申请人：——

  公开号：US20040242459A1

  公开（公告）日：2004-12-02

  A method for treating, controlling, preventing or reducing the risk of contracting an inflammatory disease or condition in a mammalian patient, comprises the steps of (1) selecting a patient in need thereof, and (2) treating the patient with a therapeutically effective amount of a composition comprising a PPAR-&dgr; agonist. Inflammatory diseases that may be treated by this method include but are not limited to rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, degenerative joint disease, one or more connective tissue diseases, ankylosing spondylitis, and bursitis.

  一种治疗、控制、预防或降低哺乳动物患者感染炎症性疾病或病症风险的方法，包括以下步骤：(1)选择有需要的患者；(2)用治疗有效量的包含 PPAR-&dgr; 激动剂的组合物治疗患者。该方法可治疗的炎症性疾病包括但不限于类风湿性关节炎、幼年类风湿性关节炎、系统性红斑狼疮、骨关节炎、退行性关节病、一种或多种结缔组织病、强直性脊柱炎和滑囊炎。
• Methods for determining whether an agent possesses a defined biological activity
  申请人：Lum Yee Pek

  公开号：US20050084872A1

  公开（公告）日：2005-04-21

  In one aspect, the present invention provides methods for determining whether an agent (e.g., candidate drug) possesses a biological activity. In another aspect, the present invention provides populations of nucleic acid molecules useful in the practice of the present invention as probes for measuring the level of expression of populations of genes.

  一方面，本发明提供了确定制剂（如候选药物）是否具有生物活性的方法。在另一个方面，本发明提供了在本发明实践中有用的核酸分子群，作为测量基因群表达水平的探针。
• ANTIDIABETIC AGENTS
  申请人：MERCK & CO., INC.

  公开号：EP0948327A1

  公开（公告）日：1999-10-13
• EP0948327A4
  申请人：——

  公开号：EP0948327A4

  公开（公告）日：2003-04-02
• EP1399151A4
  申请人：——

  公开号：EP1399151A4

  公开（公告）日：2004-08-04