甲氧基羰基膦酸 | 55920-68-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 甲氧基羰基膦酸
• 英文名称: methoxycarbonylphosphonic acid
• 英文别名: phosphonoformic acid trimethyl ester
• CAS: 55920-68-8
• 化学式: C₂H₅O₅P
• mdl: MFCD08460617
• 分子量: 140.032
• InChiKey: BGYPJLADNCZNGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  甲氧基羰基膦酸 在 草酰氯 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以90.5%的产率得到methoxycarbonyl phosphonodichloridate
  参考文献：
  名称：

  一种丙泊酚磷酰胺衍生物、其制备方法及其在医药上的用途

  摘要：

  一种丙泊酚磷酰胺衍生物、其制备方法及其在医药上的用途。本发明涉及一种通式(I)所示化合物及其立体异构体或药学上可接受的盐，以及医药中的应用，通式(I)化合物的结构如下所示，其基团定义与说明书定义一致。

  公开号：

  CN112390821A
• 作为产物：
  描述：

  (甲氧羰基)膦酸二乙酯 在 三甲基溴硅烷 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以100%的产率得到甲氧基羰基膦酸
  参考文献：
  名称：

  一种磷酸衍生物及制备方法和用途

  摘要：

  本发明涉及一种通式(I)所示化合物及其立体异构体或药学上可接受的盐，以及医药中的应用，通式(I)化合物的结构如下所示，其基团定义与说明书定义一致。

  公开号：

  CN109400645A

文献信息

• Phosphonoformic acid hydrazide compounds, their production and their
  申请人：Bayer Aktiengesellschaft

  公开号：US04308263A1

  公开（公告）日：1981-12-29

  The invention relates to phosphonoformic acid hydrazide compounds of the formula ##STR1## and salts thereof wherein R represents a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl radical. The compounds are useful as antiviral agents, particularly against herpes viruses. Also included in the invention are processes for preparing said phosphonoformic acid hydrazide compounds, compositions and medicaments containing said phosphonoformic acid hydrazide compounds and methods for the use of said compounds and compositions.

  本发明涉及式（I）的磷酸甲酰肼类化合物及其盐，其中R代表氢原子或C.sub.1-C.sub.6烷基基团。该化合物可用作抗病毒剂，特别是对抗疱疹病毒。本发明还涵盖了制备所述磷酸甲酰肼类化合物的方法，含有所述磷酸甲酰肼类化合物的组合物和药物，以及使用所述化合物和组合物的方法。
• 5′-Phosphonates of Ribonucleosides and 2′-Deoxyribonucleosides: Synthesis and Antiviral Activity
  作者：Maxim Jasko、Alexander Shipitsin、Elena Shirokova、Alexander Krayevsky、Bruce Polsky、Penny Baron、Clarinda MacLow、Michael Ostrander、Brian O'Hara

  DOI：10.1080/07328319308018558

  日期：1993.9

  5'-Phosphonates of natural 2'-deoxynucleosides and ribonucleosides were synthesized by condensation of 3'-O-acylated 2'-deoxynucleosides or 2',3'-substituted (2',3'-O-isopropylidene, 2',3'-O-methoxymethylene or 2',3'-O-ethoxymethylene) ribonucleosides. As condensing agents, either N,N'-dicyclohexylcarbodiimide or 2,4,6-triisopropylbenzenesulphonyl chloride were used. Nucleoside 5'-ethoxycarbonylphosphonates were converted into corresponding nucleoside 5'-aminocarbonylphosphonates by action of ammonia in methanol or aqueous ammonia. 5'-Hydrogenphosphonothioates of thymidine and 3'-deoxythymidine were obtained by reaction of phosphinic acid in the presence of pivaloyl chloride with 3'-O-acetylthymidine or 3'-deoxythymidine, respectively, followed by addition of powedered sulfur. 5'-O-methylenephosphonates of thymidine and 2'-deoxyadenosine were prepared by intramolecular reaction of corresponding 3'-O-iodomethylphosphonates under basic conditions. All compounds were tested for inhibition of several viruses, including HSV-2 and CMV, but showed no activity. A few compounds insignificantly inhibited HIV-1 reproduction. Thymidine 5'-hydrogenphosphonate neutralized anti-HIV action of 3'-azido-3'-deoxythymidine (AZT) and it indirectly showed that even some nucleoside 5'-phosphonates could be partly hydrolyzed in cell culture to corresponding nucleosides.