(E)-3-(1-((4-((dimethylamino)methyl)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-hydroxyacrylamide | 1266226-30-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-3-(1-((4-((dimethylamino)methyl)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-hydroxyacrylamide
• 英文别名: 3-[1-[4-[(dimethylamino)methyl]phenyl]sulfonylpyrrol-3-yl]-N-hydroxyprop-2-enamide
• CAS: 1266226-30-5
• 化学式: C₁₆H₁₉N₃O₄S
• 分子量: 349.4
• InChiKey: FECGNJPYVFEKOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel method for the production of sulphonylpyrroles as HDAC inhibitors
  申请人：4SC AG

  公开号：EP2100878A1

  公开（公告）日：2009-09-16

  Process for the preparation of a compound of formula I: wherein R1, R2, R3, R4, R5 and R6 have the meanings as defined in the specification, comprising the step of reacting an acrylic acid chloride compound of formula II': wherein R1, R2, R3, R4, R5 and R6 have the meanings as defined in the specification, with aqueous hydroxylamine and optionally converting the resulting compound into an acid addition salt thereof.

  制备化合物I的过程：其中R1、R2、R3、R4、R5和R6的含义如规范中定义的，包括与水杨酰氯化合物II'发生反应的步骤：其中R1、R2、R3、R4、R5和R6的含义如规范中定义的，与水羟胺反应，可选择地将所得化合物转化为其酸盐。
• Novel sulfonylpyrroles
  申请人：Maier Thomas

  公开号：US20070184979A1

  公开（公告）日：2007-08-09

  Compounds of the formula I in which the substitutents have the definitions provided in the specification, are novel, effective HDAC inhibitors.

  式I的化合物，其中取代基具有规范中提供的定义，是新颖、有效的HDAC抑制剂。
• Sulphonylpyrrole Hydrochloride Salts as Histone Deacetylases Inhibitors
  申请人：Maier Thomas

  公开号：US20090297473A1

  公开（公告）日：2009-12-03

  Compounds of a certain formula 1, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.

  一定化学式1的化合物，其中R1，R2，R3，R4，R5，R6和R7具有描述中指示的含义，以及它们的盐是新颖有效的HDAC抑制剂。
• NOVEL SULPHONYLPYRROLES
  申请人：MAIER Thomas

  公开号：US20110166140A1

  公开（公告）日：2011-07-07

  Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.

  具有某种式子（I）的化合物，其中R1，R2，R3，R4，R5，R6和R7具有描述中指示的含义，是新颖的有效HDAC抑制剂。
• NOVEL METHOD FOR THE PRODUCTION OF SULPHONYLPYRROLES AS HDAC INHIBITORS
  申请人：Muller Matthias

  公开号：US20110105568A1

  公开（公告）日：2011-05-05

  Process for the preparation of a compound of formula (I) wherein R1, R2, R3, R4, R5 and R6 have the meanings as defined in the specification, comprising the step of reacting an acrylic acid chloride compound of formula (II′): wherein R1, R2, R3, R4, R5 and R6 have the meanings as defined in the specification, with aqueous hydroxylamine and optionally converting the resulting compound into an acid addition salt thereof.

  制备式（I）化合物的过程，其中R1，R2，R3，R4，R5和R6具有规范中定义的含义，包括将式（II'）的丙烯酸氯化物化合物与水合肼反应，并可选择将所得化合物转化为其酸加成盐。其中R1，R2，R3，R4，R5和R6具有规范中定义的含义。