BN-82451 hydrochloride | 918656-59-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: BN-82451 hydrochloride
• 英文别名: 4-[2-(aminomethyl)-1,3-thiazol-4-yl]-2,6-ditert-butylphenol;hydrochloride
• CAS: 918656-59-4
• 化学式: C18H27ClN2OS
• 分子量: 354.9
• InChiKey: WPWBWGUPSJCKKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.99
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  87.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Use of thiazole derivatives for preparing a medicine for protecting mitochondria
  申请人：——

  公开号：US20040248885A1

  公开（公告）日：2004-12-09

  The invention concerns compounds of general formula (I), wherein: A represents one of the radicals in which R 5 represents independently a hydrogen atom, or alkyl; R 6 , R 7 and R 8 independently represent a hydrogen atom, alkyl, cycloalkyl, hydroxy or alkoxy; R 11 represents a hydrogen atom of alkyl; and R 9 , R 10 and R 12 independently represent a hydrogen atom, alkyl, hydroxy or alkoxy: B represents a hydrogen atom or alkyl; n represents an integer from 0 to 5; R 1 and R 2 independently represent a hydrogen atom, alkyl or cycloalkyl; R 3 and R 4 independently represent a hydrogen atom or an alkyl radical, or R 3 and R 4 together form with the nitrogen atom which bears them a heterocycle optionally substituted comprising in all 1 to 2 heteroatoms and 5 to 7 members. Said compounds can be used for preparing a medicine for protecting mitochondria, and in particular a medicine for preventing or treating cirrhosis. 1
• Use of thiazole derivatives for preparing a medicament intended to protect the mitochondria
  申请人：Auguet Michel

  公开号：US20070185174A1

  公开（公告）日：2007-08-09

  A method of treating Leber's syndrome in warm-blooded animals in need thereof an effective amount of a compound of the formula where the substituents are defined as in the specification.
• Thiazole Derivatives for Treating Dyskinesias Caused by a Chemical Treatment
  申请人：Chabrier De Lassauniere Pierre-Etienne

  公开号：US20080207709A1

  公开（公告）日：2008-08-28

  The invention relates to the use of derivatives of thiazoles having general formula (I) for the preparation of a medicament for the treatment or prevention of dyskinesias caused by a chemical treatment. The invention also relates to a combination of thiazole derivatives having general formula (I) and at least one compound selected from among neuroleptics or products that act on the dopaminergic system for the treatment or prevention of dyskinesias caused by a chemical treatment.
• THIAZOLE DERIVATIVES FOR TREATING DYSKINESIAS CAUSED BY A CHEMICAL TREATMENT
  申请人：Ipsen Pharma S.A.S.

  公开号：US20150238468A1

  公开（公告）日：2015-08-27

  The invention relates to the use of derivatives of thiazoles having general formula (I) for the preparation of a medicament for the treatment or prevention of dyskinesias caused by a chemical treatment. The invention also relates to a combination of thiazole derivatives having general formula (I) and at least one compound selected from among neuroleptics or products that act on the dopaminergic system for the treatment or prevention of dyskinesias caused by a chemical treatment.
• US7345066B2
  申请人：——

  公开号：US7345066B2

  公开（公告）日：2008-03-18