甲氧苄啶-磺胺嘧啶混合物 | 39474-58-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 甲氧苄啶-磺胺嘧啶混合物
• 英文名称: Tribrissen
• 英文别名: 4-amino-N-pyrimidin-2-ylbenzenesulfonamide;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
• CAS: 39474-58-3
• 化学式: C24H28N8O5S
• 分子量: 540.6
• InChiKey: NFZZDOYBSGWASD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.12
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  212
• 氢给体数：
  4
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  磺胺嘧啶 、 甲氧苄啶 以to give a sulfadiazine/trimethoprim stock solution of about 4.0/0.8 mg/ml的产率得到甲氧苄啶-磺胺嘧啶混合物
  参考文献：
  名称：

  Pharmaceutical solution and methods for preparation thereof

  摘要：

  一种液体药物溶液，其中含有抗微生物剂，有机溶剂和酸性或碱性水介质。最优选的溶液包括曲菌素，氢氧化钠，磺胺嘧啶，N-甲基吡咯烷酮和水。本发明还涉及制备这些溶液的方法。最优选的组成包括：曲菌素约为每毫升液体药物溶液40毫克；磺胺嘧啶约为每毫升液体药物溶液200毫克；N-甲基吡咯烷酮约为每毫升液体药物溶液514毫克，氢氧化钠约为每毫升液体药物溶液30毫克和水。制备药物溶液的方法包括按任何顺序组合以下物质：曲菌素，N-甲基吡咯烷酮，磺胺嘧啶和酸性或碱性水介质。液体药物溶液还可以添加其他添加剂，如抗氧化剂和防腐剂。

  公开号：

  US05707996A1

文献信息

• Systems methods and devices for closed loop stimulation to enhance stroke recovery
  申请人：Regents of the University of California

  公开号：US11147971B2

  公开（公告）日：2021-10-19

  Systems, methods and devices for promoting recovery from a stroke induced loss of motor function in a subject. In certain aspects, the system includes at least one electrode, and an operations system in electrical communication with at least one electrode, wherein the at least one electrode is constructed and arranged to apply current across the brain of the subject and to record low frequency oscillations from a perilesional region of the subject. In certain aspects, provided is a method comprising placing at least one recording electrode in electrical communication in a perilesional region of the subject; placing at least one stimulation electrode in electrical communication with the brain of the subject; recording low frequency oscillations from the perilesional region of the subject; and delivering current stimulation to the brain of the subject.

  用于促进受试者从中风引起的运动功能丧失中恢复的系统、方法和设备。在某些方面，该系统包括至少一个电极，以及与至少一个电极进行电气通信的操作系统，其中至少一个电极被构造和布置成在受试者的大脑中施加电流，并记录来自受试者颅周区域的低频振荡。在某些方面，提供了一种方法，该方法包括将至少一个记录电极置于受试者的肛周区域，与之进行电气通信；将至少一个刺激电极置于与受试者大脑进行电气通信的位置；记录来自受试者肛周区域的低频振荡；以及向受试者的大脑施加电流刺激。
• METHODS AND COMPOSITIONS FOR USE IN AQUACULTURE
  申请人：Chemaphor Inc.

  公开号：EP2536293A1

  公开（公告）日：2012-12-26
• SYSTEMS METHODS AND DEVICES FOR CLOSED-LOOP STIMULATION TO ENHANCE STROKE RECOVERY
  申请人：Regents of the University of California

  公开号：EP3458147A1

  公开（公告）日：2019-03-27
• IMMEDIATE RELEASE PHARMACEUTICAL GRANULE COMPOSITIONS AND A CONTINUOUS PROCESS FOR MAKING THEM
  申请人：Remon Jean Paul

  公开号：US20110008454A1

  公开（公告）日：2011-01-13

  A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from 0.5% to 20% by weight of the composition, and excipients, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by weight to 80% by weight of said composition, (iii) a wetting amount of a second excipient being a polyethylene glycol having a weight number molecular weight between 300 and 5,000, said second excipient comprising a solid fraction and a liquid fraction, and representing from 15% to 40% by weight of said composition, and optionally one or more pharmaceutically acceptable fillers selected from the group consisting of hydrocolloids, glidants, lubricants, surfactants and diluents, wherein the weight ratio of said first excipient (ii) to said second excipient (iii) is in a range from 1:1 to 5:1.
• METHOD AND APPARATUS FOR PACKAGING AND DISPENSING PHARMACEUTICALS
  申请人：Tramonte Arturo

  公开号：US20110240504A1

  公开（公告）日：2011-10-06

  A method of packaging one or more pharmaceuticals comprising separating a plurality of unit doses into a plurality of unit dose compartments, wherein each unit dose compartment of the plurality of unit dose compartments holds only one unit dose of the plurality of unit doses, each unit dose having the same strength, wherein the plurality of unit doses is precisely a quantity equal to a most commonly prescribed number of unit doses in individual prescriptions for the unit dose, or a multiple thereof is provided. Also provided are kits prepared by the method. Methods for designing such kits and packaging are also provided.