2-[4-(4-pyridin-4-yl-N-(4-pyridin-4-ylphenyl)anilino)phenyl]ethane-1,1,2-tricarbonitrile | 1449315-90-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[4-(4-pyridin-4-yl-N-(4-pyridin-4-ylphenyl)anilino)phenyl]ethane-1,1,2-tricarbonitrile
• CAS: 1449315-90-5
• 化学式: C₃₃H₂₂N₆
• 分子量: 502.578
• InChiKey: BEAMVZWQYWJUDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  100
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-[双(4-碘苯基)氨基]苯甲醛 在 四(三苯基膦)钯 、 ammonium acetate 、 水 、 caesium carbonate 、 溶剂黄146 作用下， 以 甲苯 为溶剂， 反应 8.0h， 生成 2-[4-(4-pyridin-4-yl-N-(4-pyridin-4-ylphenyl)anilino)phenyl]ethane-1,1,2-tricarbonitrile
  参考文献：
  名称：

  A new triphenylamine fluorescent dye for sensing of cyanide anion in living cell

  摘要：

  A triphenylamine-based fluorescent probe 1 with larger Stokes shift (similar to 141 nm) has been synthesized, which can make an efficient nucleophilic addition by reacting with CN- in water. Upon addition of CN-, the red fluorescence of 1 was distinctly quenched. Importantly, 1 exhibits a highly selective response toward CN- over other anions in water and a high sensitivity (detection limit <= 11 nM). More-over, it has potential application to track CN- levels in living cells by confocal laser scanning microscopy (CLSM). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.07.011

文献信息

• A new triphenylamine fluorescent dye for sensing of cyanide anion in living cell
  作者：Yi Qu、Bin Jin、Yi Liu、Yongquan Wu、Lin Yang、Junchen Wu、Jianli Hua

  DOI：10.1016/j.tetlet.2013.07.011

  日期：2013.9

  A triphenylamine-based fluorescent probe 1 with larger Stokes shift (similar to 141 nm) has been synthesized, which can make an efficient nucleophilic addition by reacting with CN- in water. Upon addition of CN-, the red fluorescence of 1 was distinctly quenched. Importantly, 1 exhibits a highly selective response toward CN- over other anions in water and a high sensitivity (detection limit <= 11 nM). More-over, it has potential application to track CN- levels in living cells by confocal laser scanning microscopy (CLSM). (C) 2013 Elsevier Ltd. All rights reserved.