7-Benzyl-6-fluoro-7H-purine | 150721-87-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-Benzyl-6-fluoro-7H-purine
• 英文别名: 7-benzyl-6-fluoropurine
• CAS: 150721-87-2
• 化学式: C₁₂H₉FN₄
• 分子量: 228.229
• InChiKey: IHGLFBAXMWGJOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-氟嘌呤 、 苯甲醇 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 以16%的产率得到7-Benzyl-6-fluoro-7H-purine
  参考文献：
  名称：

  Mitsunobu Reactions for the Synthesis of Carbocyclic Analogues of Nucleosides: Examination of the Regioselectivity¹

  摘要：

  In order to provide a general synthetic method for carbocyclic nucleosides, regioselectivities in Mitsunobu reaction of purine, pyrimidin-2-one and their substituted derivatives with a variety of alcohols were examined and found to depend upon both substituents of the bases and kind of the alcohols.

  DOI：

  10.1080/00397919308011216

文献信息

• Mitsunobu Reactions for the Synthesis of Carbocyclic Analogues of Nucleosides: Examination of the Regioselectivity¹
  作者：Akemi Toyota、Nobuya Katagiri、Chikara Kaneko

  DOI：10.1080/00397919308011216

  日期：1993.5

  In order to provide a general synthetic method for carbocyclic nucleosides, regioselectivities in Mitsunobu reaction of purine, pyrimidin-2-one and their substituted derivatives with a variety of alcohols were examined and found to depend upon both substituents of the bases and kind of the alcohols.