Methyl 2,4-dichloro-6-fluorobenzoate | 1398504-37-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2,4-dichloro-6-fluorobenzoate
• 英文别名: methyl 2,4-dichloro-6-fluorobenzoate
• CAS: 1398504-37-4
• 化学式: C₈H₅Cl₂FO₂
• 分子量: 223.02
• InChiKey: NYSVGJCOIGNBSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Carboxamides as modulators of sodium channels
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：US10647661B2

  公开（公告）日：2020-05-12

  Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

  提供了可用作钠通道抑制剂的化合物及其药学上可接受的盐。还提供了包含这些化合物或药学上可接受的盐的药物组合物，以及使用这些化合物、药学上可接受的盐和药物组合物治疗各种疾病（包括疼痛）的方法。
• CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：US20190016671A1

  公开（公告）日：2019-01-17

  Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.