2,4-Diaminonicotinamide | 1379323-59-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,4-Diaminonicotinamide
• 英文别名: 2,4-diaminopyridine-3-carboxamide
• CAS: 1379323-59-7
• 化学式: C₆H₈N₄O
• 分子量: 152.15
• InChiKey: ROEFSAYMYUHTTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• TREATMENT OF PERITONEAL INJURY USING JAK INHIBITORS
  申请人：Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

  公开号：US20130303563A1

  公开（公告）日：2013-11-14

  The invention provides, in certain embodiments, a method of preventing and/or treating peritoneal injury and/or diminished function by administering an effective amount of one or more inhibitors of JAK. The invention also provides a pharmaceutical composition including a JAK inhibitor for the treatment of peritoneal injury and/or diminished function. In another aspect, the invention provides a method of detecting an indicator of peritoneal injury. The method entails assaying a biological sample for periostin, wherein the presence of periostin at an elevated level indicates the presence and/or degree of peritoneal injury. Also provided, are methods of identifying subject for treatment of peritoneal injury and/or diminished function, methods of determining progression of these conditions, as well as methods of determining subjects' response to treatment.
• US9198900B2
  申请人：——

  公开号：US9198900B2

  公开（公告）日：2015-12-01