N-(5-Morpholin-4-yl-pyridin-2-yl)-acetamide | 909570-15-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(5-Morpholin-4-yl-pyridin-2-yl)-acetamide
• 英文别名: N-(5-morpholinopyridin-2-yl)acetamide；N-(5-morpholin-4-ylpyridin-2-yl)acetamide
• CAS: 909570-15-6
• 化学式: C₁₁H₁₅N₃O₂
• mdl: MFCD12236090
• 分子量: 221.259
• InChiKey: ABHBSTNFIZLRTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吗啉 、 2-乙酰氨基-5-溴吡啶 在 copper(l) iodide 、 potassium carbonate 、 DL-脯氨酸 作用下， 以 二甲基亚砜 为溶剂， 反应 15.0h， 以58%的产率得到N-(5-Morpholin-4-yl-pyridin-2-yl)-acetamide
  参考文献：
  名称：

  Practical Cu-catalyzed amination of functionalized heteroaryl halides

  摘要：

  The amination of a variety of highly functionalized heterocyclic bromides has been accomplished using a CuI/proline catalyst system. The current study significantly expanded the scope of the reaction by using examples relevant to drug discovery programs and has demonstrated reaction rate acceleration using microwave heating. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.06.119

文献信息

• Practical Cu-catalyzed amination of functionalized heteroaryl halides
  作者：Vince S.C. Yeh、Paul E. Wiedeman

  DOI：10.1016/j.tetlet.2006.06.119

  日期：2006.8

  The amination of a variety of highly functionalized heterocyclic bromides has been accomplished using a CuI/proline catalyst system. The current study significantly expanded the scope of the reaction by using examples relevant to drug discovery programs and has demonstrated reaction rate acceleration using microwave heating. (c) 2006 Elsevier Ltd. All rights reserved.