3-乙基-2,4-二甲基吡咯烷 | 5666-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 3-乙基-2,4-二甲基吡咯烷
• 英文名称: 2,4-dimethyl-3-ethylpyrrolidine
• 英文别名: 3-ethyl-2,4-dimethyl-pyrrolidine；3-Aethyl-2,4-dimethyl-pyrrolidin；3-Ethyl-2,4-dimethylpyrrolidine
• CAS: 5666-10-4
• 化学式: C₈H₁₇N
• mdl: MFCD00086624
• 分子量: 127.23
• InChiKey: GTDYINNWQOHUAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2-(2-bromo-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)-1-(3,5-di-tert-butyl-4-hydroxyphenyl)ethan-1-one 、 3-乙基-2,4-二甲基吡咯烷 反应 4.0h， 生成 1-(3,5-Ditert-butyl-4-hydroxyphenyl)-2-[2-(3-ethyl-2,4-dimethylpyrrolidin-1-yl)-5,6-dimethylbenzimidazol-1-yl]ethanone
  参考文献：
  名称：

  Selective benzimidazole inhibitors of the antigen receptor-mediated NF-κB activation pathway

  摘要：

  Dysregulated antigen receptor-mediated NF-kappa B activation can contribute to development of autoimmunity, chronic inflammation, and malignancy. A chemical biology screening strategy has identified a substituted benzimidazole that selectively inhibits antigen receptor-mediated NF-kappa B activation without blocking other NF-kappa B activation pathways. A library of analogs was synthesized and the structure-activity relationship and metabolic stability for the series is presented. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.01.039
• 作为产物：
  描述：

  2,4-二甲基-3-乙基吡咯 在 磷化氢 、 氢碘酸 作用下， 生成 3-乙基-2,4-二甲基吡咯烷
  参考文献：
  名称：

  Willstaetter; Asahina, Chemische Berichte, 1911, vol. 44, p. 3709

  摘要：

  DOI：

文献信息

• CAPTURE AGENTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
  申请人：Agnew Heather

  公开号：US20110263515A1

  公开（公告）日：2011-10-27

  Multi-ligand capture agents comprising two or more ligands are described, and related compositions, methods and systems.

  本文描述了包括两个或更多配体的多配体捕获剂，以及相关的组合物、方法和系统。
• Stress and Depressive Symptoms Among Mexican American Elders
  作者：D. A. Chiriboga、S. A. Black、M. Aranda、K. Markides

  DOI：10.1093/geronb/57.6.p559

  日期：2002.11.1

  Although social stressors have successfully predicted depressive symptomatology in a number of populations, few studies have examined the relevance of stressors for Mexican American elders. Results are reported here from a multistage probability sample of 3,050 Mexican Americans aged 65 and older drawn from a 5-state region. Participants reported low levels of education and income, and most reported difficulty in reading or writing in English. Deaths, illness of close other, and financial problems were the three most frequent life events, and many reported financial strains. Depressive symptoms were then regressed on demographic indicators, cognitive status, linguistic acculturation, social supports, and three types of stressors. Being a woman, lower income, decreased income, chronic financial strain, and several health stressors were associated with greater symptomatology. Results identified a cluster of economic stressors and conditions that may play a critical role in the etiology of depressive symptoms in this minority population.
• SUBSTITUTED PYRROLIDINES AND PYRROLIDYLETHANOLS¹
  作者：ROBERT BRUCE MOFFETT、JOHN L. WHITE

  DOI：10.1021/jo01137a013

  日期：1952.3
• INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION
  申请人：Abbott Laboratories

  公开号：EP1250332A1

  公开（公告）日：2002-10-23
• KRAFT- UND SCHMIERSTOFFADDITIV-KONZENTRATE, ENTHALTEND MINDESTENS EIN ANTHRACHINON-DERIVAT ALS MARKIERUNGSSTOFF
  申请人：BASF Aktiengesellschaft

  公开号：EP1699907A1

  公开（公告）日：2006-09-13