N-(1-butoxy-2,2,6,6-tetramethylpiperidin-4-yl)-5-(dimethylamino)naphthalene-1-sulfonamide | 1395814-64-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(1-butoxy-2,2,6,6-tetramethylpiperidin-4-yl)-5-(dimethylamino)naphthalene-1-sulfonamide
• CAS: 1395814-64-8
• 化学式: C₂₅H₃₉N₃O₃S
• 分子量: 461.669
• InChiKey: XRIHKGBJPSBDNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  70.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  在 sodium azide 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 二甲基亚砜 、 甲苯 为溶剂， 反应 19.5h， 生成 N-(1-butoxy-2,2,6,6-tetramethylpiperidin-4-yl)-5-(dimethylamino)naphthalene-1-sulfonamide
  参考文献：
  名称：

  Urushiol Detection using a Profluorescent Nitroxide

  摘要：

  A method to visually detect minute amounts of urushiol, the toxic catechol from poison oak, poison ivy, and poison sumac, has been developed utilizing the reaction of a profluorescent nitroxide with the B-n-butylcatecholboronate ester formed in situ from urushiol and B-n-butylboronic acid. The resulting N-alkoxyamine is strongly fluorescent upon illumination with a fluorescent lamp, allowing the location of the toxic urushiol contamination to be visualized. This methodology constitutes the groundwork for the future development of a spray to detect urushiol to avoid contact dermatitis, as well as to detect catecholamines for biomedical applications.

  DOI：

  10.1021/jo301135m

文献信息

• FLUORESCENCE DETECTION OF POISON OAK OIL
  申请人：The Regents of the University of California

  公开号：US20130121924A1

  公开（公告）日：2013-05-16

  The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.

  本公开的发明提供了用于合成所述组合物的方法，以及使用所述组合物的方法，其中这些组合物和方法可用于结合和/或使毒橡树油（如漆酚）失活。这些组合物和方法可用于治疗和/或减轻对毒橡树、毒藤、毒漆树、芒果、漆树和腰果中发现的天然化合物的炎症反应和/或过敏反应。
• Urushiol Detection using a Profluorescent Nitroxide
  作者：Rebecca Braslau、Frank Rivera、Erin Lilie、MariEllen Cottman

  DOI：10.1021/jo301135m

  日期：2013.1.18

  A method to visually detect minute amounts of urushiol, the toxic catechol from poison oak, poison ivy, and poison sumac, has been developed utilizing the reaction of a profluorescent nitroxide with the B-n-butylcatecholboronate ester formed in situ from urushiol and B-n-butylboronic acid. The resulting N-alkoxyamine is strongly fluorescent upon illumination with a fluorescent lamp, allowing the location of the toxic urushiol contamination to be visualized. This methodology constitutes the groundwork for the future development of a spray to detect urushiol to avoid contact dermatitis, as well as to detect catecholamines for biomedical applications.