SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD
申请人:Cheng T. W. Peter
公开号:US20070287713A1
公开(公告)日:2007-12-13
wherein
Z
1
is (CH
2
)
q
or C═O;
Z
2
is (CH
2
)
p
or C═O;
D is —CH═ or C═O or (CH
2
)
m
where m is 0, 1, 2 or 3; n=0, 1 or 2; p=1 or 2; q=0, 1 or 2; Q is C or N;
A is (CH
2
)
x
where x is 1 to 5, or A is (CH
2
)
x
1
, where x
1
is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is —(CH
2
)
x
2
—O—(CH
2
)
x
3
— where x
2
is 0 to 5 and x
3
is 0 to 5, provided that at least one of x
2
and x
3
is other than 0;
B is a bond or is (CH
2
)
x
4
where x
4
is 1 to 5; X is CH or N;
X
2
is C, N, O or S;
X
3
is C, N, O or S;
X
4
is C, N, O or S;
X
5
is C, N, O or S;
X
6
is C, N, O or S;
provided that at least one of X
2
, X
3
, X
4
X
5
and X
6
is N; and at least one of X
2
, X
3
, X
4
X
5
and X
6
is C.
R
1
is H or alkyl;
R
2
is H, alkyl, alkoxy, halogen, amino, substituted amino or cyano;
R
2a
, R
2b
and R
2c
may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; and
R
3
, E, Z and Y are as defined herein.
其中Z1为(CH2)q或C═O;Z2为(CH2)p或C═O;D为—CH═或C═O或(CH2)m,其中m为0、1、2或3;n=0、1或2;p=1或2;q=0、1或2;Q为C或N;A为(CH2)x,其中x为1到5,或A为(CH2)x1,其中x1为1到5,具有烯丙基键或炔基键嵌入链中的任何位置,或A为—(CH2)x2—O—(CH2)x3—,其中x2为0到5,x3为0到5,前提是x2和x3中至少有一个不为0;B为键或(CH2)x4,其中x4为1到5;X为CH或N;X2、X3、X4、X5和X6为C、N、O或S;前提是X2、X3、X4、X5和X6中至少有一个为N;并且X2、X3、X4、X5和X6中至少有一个为C。R1为H或烷基;R2为H、烷基、烷氧基、卤素、氨基、取代氨基或氰基;R2a、R2b和R2c可以相同也可以不同,选择自H、烷基、烷氧基、卤素、氨基、取代氨基或氰基;而R3、E、Z和Y的定义如前所述。