N-diphenylphosphoryl-N-pyridin-3-ylpyridin-3-amine | 1418758-32-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-diphenylphosphoryl-N-pyridin-3-ylpyridin-3-amine
• CAS: 1418758-32-3
• 化学式: C₂₂H₁₈N₃OP
• 分子量: 371.378
• InChiKey: LQVYUDPCNNIYBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  di(pyridin-3-yl)amine 、 二苯基次膦酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以50%的产率得到N-diphenylphosphoryl-N-pyridin-3-ylpyridin-3-amine
  参考文献：
  名称：

  Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5

  摘要：

  Diphenylphosphinic amides and diphenylphosphine oxides have been synthesized and tested as inhibitors of the Kv1.5 potassium ion channel as a possible treatment for atrial fibrillation. In vitro structure-activity relationships are discussed and several compounds with Kv1.5 IC50 values of <0.5 mu M were discovered. Selectivity over the ventricular IKs current was monitored and selective compounds were found. Results from a rabbit PD-model are included. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.11.098

文献信息

• Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5
  作者：Roine I. Olsson、Ingemar Jacobson、Jonas Boström、Tomas Fex、Annika Björe、Christina Olsson、Johan Sundell、Ulrik Gran、Anna Öhrn、Andreas Nordin、Jonna Gyll、Maria Thorstensson、Ahlke Hayen、Karolina Aplander、Olle Hidestål、Fanyi Jiang、Gunilla Linhardt、Elin Forsström、Teresa Collins、Monika Sundqvist、Emma Lindhardt、Annika Åstrand、Boel Löfberg

  DOI：10.1016/j.bmcl.2012.11.098

  日期：2013.2

  Diphenylphosphinic amides and diphenylphosphine oxides have been synthesized and tested as inhibitors of the Kv1.5 potassium ion channel as a possible treatment for atrial fibrillation. In vitro structure-activity relationships are discussed and several compounds with Kv1.5 IC50 values of <0.5 mu M were discovered. Selectivity over the ventricular IKs current was monitored and selective compounds were found. Results from a rabbit PD-model are included. (c) 2012 Elsevier Ltd. All rights reserved.