3-乙氧基-2-(苯磺酰)丙烯腈 | 32083-50-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-乙氧基-2-(苯磺酰)丙烯腈
• 英文名称: 2-(benzenesulfonyl)-3-ethoxyprop-2-enenitrile
• 英文别名: 2-Phenylsulfonyl-3-aethoxyacrylnitril；3-Ethoxy-2-(phenylsulfonyl)acrylonitrile；(E)-2-(benzenesulfonyl)-3-ethoxyprop-2-enenitrile
• CAS: 32083-50-4
• 化学式: C₁₁H₁₁NO₃S
• 分子量: 237.279
• InChiKey: PUKBSEPGZUQYAT-PKNBQFBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  75.5
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2926909090

反应信息

• 作为反应物：
  描述：

  3-乙氧基-2-(苯磺酰)丙烯腈 、 磺胺噻唑 以61%的产率得到
  参考文献：
  名称：

  NEPLYUEV V. M.; SINENKO T. A.; XOJNA E. V., UKR. XIM. ZH., 1979, 45, HO 6, 547-548

  摘要：

  DOI：

文献信息

• Synthesis of methyl 3-amino-4-aryl(or methyl)sulfonyl-2-thiophenecarboxylates from 3-alkoxy-2-aryl(or methyl)-sulfonylacrylonitriles
  作者：Chad E. Stephens、Matthew B. Price、J. Walter Sowell

  DOI：10.1002/jhet.5570360314

  日期：1999.5

  The synthesis of a series of methyl 3-amino-4-aryl(or methyl)sulfonylthiophene-2-carboxylates by reaction of 3-alkoxy-2-aryI(or methyl)sulfonylacrylonitriles with methyl thioglycolate in the presence of triethylamine is described. Hydrolysis/decarboxylation of the ester at the 2-position and acylation of the resulting amine represents a convenient route to 4-arylsulfonyl-3-carboxamidothiophenes. Attempted

  描述了在三乙胺存在下，通过3-烷氧基-2-芳基（或甲基）磺酰基丙烯腈与硫代乙醇酸甲酯的反应，合成一系列3-氨基-4-芳基（或甲基）磺酰基噻吩-2-羧酸甲酯。酯在2-位的水解/脱羧和所得胺的酰化代表了形成4-芳基磺酰基-3-羧酰胺基噻吩的便利途径。在标准条件下尝试酰化标题氨基噻吩未成功。
• DALLA, CROCE, P.;LA, ROSA, C.;ZECCHI, G., J. CHEM. SOC. PERKIN TRANS., 1985, N 12, 2621-2624
  作者：DALLA, CROCE, P.、LA, ROSA, C.、ZECCHI, G.

  DOI：——

  日期：——
• NEPLYUEV V. M.; SINENKO T. A.; PELKIS P. S., XIMIYA GETEROTSIKL. SOEDIN., 1978, HO 7, 969-971
  作者：NEPLYUEV V. M.、 SINENKO T. A.、 PELKIS P. S.

  DOI：——

  日期：——
• NEPLYUEV V. M.; KUXAR V. P.; SINENKO T. A.; XOJNA E. V.; PELKIS P. S., ZH. ORGAN. XIMII, 1978, 14, HO 9, 1947-1953
  作者：NEPLYUEV V. M.、 KUXAR V. P.、 SINENKO T. A.、 XOJNA E. V.、 PELKIS P. S.

  DOI：——

  日期：——
• PROCESS FOR PRODUCING 5-AMINOPYRAZOLE DERIVATIVE, AND AZO DYE
  申请人：Tateishi Keiichi

  公开号：US20100063262A1

  公开（公告）日：2010-03-11

  A process for producing a 5-aminopyrazole derivative represented by Formula (I) includes a step of reacting a hydrazine compound represented by Formula (II) with a compound represented by Formula (III) under a condition satisfying Reaction Condition 1 and Reaction Condition 2, wherein Reaction Condition 1 is that the reaction is conducted in a reaction solvent containing water, and Reaction Condition 2 is that pH of a liquid mixture containing the hydrazine compound represented by Formula (II), the compound represented by Formula (III), the reaction solvent, and an acidifying agent upon charging is within a range of from 2.0 to 4.0 at 25° C.: wherein the symbols in the formulae (I) to (III) are defined in the specification.