Tert-butyl 4-(bromomethyl)-4-[3-chloro-2-[(4-nitrophenyl)sulfonylamino]propoxy]piperidine-1-carboxylate | 1402011-56-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tert-butyl 4-(bromomethyl)-4-[3-chloro-2-[(4-nitrophenyl)sulfonylamino]propoxy]piperidine-1-carboxylate
• 英文别名: tert-butyl 4-(bromomethyl)-4-[3-chloro-2-[(4-nitrophenyl)sulfonylamino]propoxy]piperidine-1-carboxylate
• CAS: 1402011-56-6
• 化学式: C₂₀H₂₉BrClN₃O₇S
• 分子量: 570.889
• InChiKey: ZOJFTRASEFJRST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  139
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-硝基苯磺酰胺 、 N-Boc-4-亚甲基哌啶 、 环氧氯丙烷 在 N-溴代丁二酰亚胺(NBS) 作用下， 反应 16.0h， 生成 Tert-butyl 4-(bromomethyl)-4-[3-chloro-2-[(4-nitrophenyl)sulfonylamino]propoxy]piperidine-1-carboxylate 、 tert-butyl 4-(bromomethyl)-4-(1-chloro-3-(4-nitrophenylsulfonamido)propan-2-yloxy)piperidine-1-carboxylate
  参考文献：
  名称：

  Multicomponent Approach in the Synthesis of 2,2,6-Trisubstituted Morpholine Derivatives

  摘要：

  An efficient synthesis of 2,2,6-trisubstituted morpholine is described which involves a multicomponent process by simply mixing epichlorohydrin, N-bromosuccinimide, nosyl amide, and an olefin. The products contain chloride handles which are suitable for further modification.

  DOI：

  10.1021/ol3024105

文献信息

• Multicomponent Approach in the Synthesis of 2,2,6-Trisubstituted Morpholine Derivatives
  作者：Jing Zhou、Ling Zhou、Ying-Yeung Yeung

  DOI：10.1021/ol3024105

  日期：2012.10.19

  An efficient synthesis of 2,2,6-trisubstituted morpholine is described which involves a multicomponent process by simply mixing epichlorohydrin, N-bromosuccinimide, nosyl amide, and an olefin. The products contain chloride handles which are suitable for further modification.