(2E)-3-{4-[(1E)-3-(3-fluorophenyl)-3-oxoprop-1-en-1-yl]-1-methylpyrrol-2-yl}-N-hydroxyprop-2-enamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2E)-3-{4-[(1E)-3-(3-fluorophenyl)-3-oxoprop-1-en-1-yl]-1-methylpyrrol-2-yl}-N-hydroxyprop-2-enamide
• 英文别名: 3-[4-[3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-N-hydroxyprop-2-enamide
• 化学式: C₁₇H₁₅FN₂O₃
• 分子量: 314.31
• InChiKey: QRDAPCMJAOQZSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  71.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• System and Method of Producing Volatile Organic Compounds from Fungi
  申请人：Strobel Gary A.

  公开号：US20130137131A1

  公开（公告）日：2013-05-30

  An isolated fungus is described. The isolated fungus produces at least one compound selected from the group consisting of 1,8-cineole, 1-methyl-1, 4-cyclohexadiene, and (+)-α-methylene-α-fenchocamphorone. A method for producing at least one compound selected from the group consisting of 1,8-cineole, 1-methyl-1, 4-cyclohexadiene, and (+)-α-methylene-α-fenchocamphorone is also described. The method includes culturing a fungus on or within a culturing media in a container under conditions sufficient for producing the at least one compound.
• MODULATION OF REACTIVATION OF A LATENT VIRUS
  申请人：THE UNIVERSITY OF CHICAGO

  公开号：US20160089376A1

  公开（公告）日：2016-03-31

  The disclosure relates to methods of controlling the state of a virus (lytic or lysogenic) in an individual, such as a method of reactivating a latent virus in an individual, comprising administering one or more agents that modulates the activity of signal transducer and activator of transcription 3 (STAT3) or any of p300, CBP or p300/CBP. Also contemplated are methods further comprising administering an HDAC modulating agent, such as an HDAC inhibiting agent or an HDAC activating agent.
• US9624515B2
  申请人：——

  公开号：US9624515B2

  公开（公告）日：2017-04-18
• US9669036B2
  申请人：——

  公开号：US9669036B2

  公开（公告）日：2017-06-06
• [EN] MODULATION OF REACTIVATION OF A LATENT VIRUS<br/>[FR] MODULATION DE LA RÉACTIVATION D'UN VIRUS LATENT
  申请人：UNIV CHICAGO

  公开号：WO2014185973A2

  公开（公告）日：2014-11-20

  The disclosure relates to methods of controlling the state of a virus (lytic or lysogenic) in an individual, such as a method of reactivating a latent virus in an individual, comprising administering one or more agents that modulates the activity of signal transducer and activator of transcription 3 (STAT3) or any of p300, CBP or p300/CBP. Also contemplated are methods further comprising administering an HDAC modulating agent, such as an HDAC inhibiting agent or an HDAC activating agent.