3-Nitro-4-({4-[(trifluoromethyl)sulfanyl]phenyl}methoxy)benzaldehyde | 819076-63-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Nitro-4-({4-[(trifluoromethyl)sulfanyl]phenyl}methoxy)benzaldehyde
• 英文别名: 3-nitro-4-[[4-(trifluoromethylsulfanyl)phenyl]methoxy]benzaldehyde
• CAS: 819076-63-6
• 化学式: C15H10F3NO4S
• 分子量: 357.3
• InChiKey: DUCCJHRWDRCXOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  97.4
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSES CHIMIQUES
  申请人：IONIX PHARMACEUTICALS LTD

  公开号：WO2005000309A2

  公开（公告）日：2005-01-06

  Compounds of the formulae (I) and (II), and pharmaceutically acceptable salts thereof, are found to be inhibitors of sensory neurone specific (SNS) sodium channels. They are therefore useful as analgesic and neuroprotective agents. Formula (I) & Formula (II) wherein, in the formula (I), R1 is an organic substituent, X1 and X2 are direct bonds or spacer moieties, Ar is aryl or heteroaryl and Y is a substituted aminoalkyl group or a heteroaryl-, heterocyclyl- or phenyl-containing moiety and, in the formula(II), R1, R2, R3, Ar and R4 are organic substituents, X is a spacer moiety and Het is a 5-membered heteroaryl or heterocyclyl group.