1-(1-Azidoethyl)-3-(trifluoromethyl)benzene | 823189-14-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(1-Azidoethyl)-3-(trifluoromethyl)benzene
• 英文别名: 1-(1-azidoethyl)-3-(trifluoromethyl)benzene
• CAS: 823189-14-6
• 化学式: C9H8F3N3
• 分子量: 215.17
• InChiKey: JHDGMKSGIXTNEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  14.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NOVEL BENZYLAMINO SUBSTITUTED PYRIDOPYRIMIDINONES AND DERIVATIVES AS SOS1 INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20210009588A1

  公开（公告）日：2021-01-14

  The present invention encompasses compounds of formula (1) wherein the groups R 1 to R 4 , A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.