3-吡咯烷磺酸,1-[4-(2,5-二氢-2,5-二羰基-1H-吡咯-1-基)-1-羰基丁氧基]-2,5-二羰基- | 158018-81-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 3-吡咯烷磺酸,1-[4-(2,5-二氢-2,5-二羰基-1H-吡咯-1-基)-1-羰基丁氧基]-2,5-二羰基-
• 英文名称: 1-((4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoyl)oxy)-2,5-dioxopyrrolidine-3-sulfonic acid
• 英文别名: 1-[4-(2,5-dioxopyrrol-1-yl)butanoyloxy]-2,5-dioxopyrrolidine-3-sulfonic acid
• CAS: 158018-81-6
• 化学式: C₁₂H₁₂N₂O₉S
• 分子量: 360.3
• InChiKey: LCZVQHWMSQLWSC-UHFFFAOYSA-N

物化性质

• 密度：
  1.76±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  164
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] CLEAVABLE NUCLEOTIDE ANALOGS AND USES THEREOF<br/>[FR] ANALOGUES NUCLÉOTIDIQUES CLIVABLES ET LEURS UTILISATIONS
  申请人：HARVARD COLLEGE

  公开号：WO2018102554A1

  公开（公告）日：2018-06-07

  Cleavable nucleotide analogs are provided. The nucleotide analog includes a nucleotide molecule attached to a cleavable moiety wherein the cleavable moiety comprises a protective group and/or a linker attached to a fluorophore. The cleavable moiety is linked to the oxygen atom of the 3'-OH of the pentose of the nucleotide molecule. The nucleotide analogs can be used in making polynucleotide molecules using template independent polymerases. The nucleotide analogs can act as reversible terminators during DNA sequencing by synthesis. The cleavage of the cleavable moiety restores a free 3'-OH functional group allowing growth of the polynucleotide molecule. The general structures as well as proposed synthetic schemes for the nucleotide analogs are also provided.

  可切割的核苷酸类似物已提供。该核苷酸类似物包括连接到可切割基团的核苷酸分子，其中可切割基团包括保护基团和/或连接到荧光团的连接物。可切割基团连接到核苷酸分子的五碳糖的3'-OH的氧原子。这些核苷酸类似物可用于使用模板无关聚合酶制备多核苷酸分子。这些核苷酸类似物在DNA合成测序过程中可作为可逆终止子。切割可切割基团恢复自由的3'-OH官能团，从而促进多核苷酸分子的生长。还提供了核苷酸类似物的一般结构以及拟议的合成方案。
• Photocleavable isotope-coded affinity tags
  申请人：Olejnik Jerzy

  公开号：US20050085630A1

  公开（公告）日：2005-04-21

  This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as proteins and protein fragments from biological samples from in vivo and in vitro sources. Agents comprise a detectable group bound to a photoreactive group. Conjugates comprise agents coupled to substrates by covalent bounds which can be selectively cleaved with the administration of electromagnetic radiation. Targets substances labeled with detectable molecules can be easily identified and separated from a heterologous mixture of substances. Exposure of the conjugate to radiation releases the target in a functional form and completely unaltered. Using photocleavable molecular precursors as the conjugates, label can be incorporated into macromolecules, the nascent macromolecules isolated and the label completely removed. The invention also relates to targets isolated with these conjugates which may be useful as pharmaceutical agents or compositions that can be administered to humans and other mammals.

  本发明涉及可以用于检测和分离来自复杂混合物（如来自体内和体外源的生物样本中的蛋白质和蛋白质片段）的靶组分的试剂和结合物。试剂包括结合到光反应基团的可检测基团。结合物包括通过共价键结合到底物的试剂，这些共价键可以通过电磁辐射的施加而选择性地断裂。标记有可检测分子的目标物质可以很容易地从异源混合物中识别和分离出来。将结合物暴露于辐射会释放出目标物质以功能形式完全不变。使用光解分子前体作为结合物，标记可以被结合到大分子中，新生大分子被分离并标记完全去除。该发明还涉及使用这些结合物分离出的目标物质，这些目标物质可能作为药用剂或可用于给人类和其他哺乳动物的组合物。
• [EN] N-1 BRANCHED IMIDAZOQUINOLINES, CONJUGATES THEREOF, AND METHODS<br/>[FR] IMIDAZOQUINOLINES RAMIFIÉES N-1, CONJUGUÉS DE CELLES-CI ET PROCÉDÉS
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2022008995A1

  公开（公告）日：2022-01-13

  Imidazoquinoline compounds, salts thereof, conjugates thereof, pharmaceutical compositions containing the compounds and conjugates, and methods of use of such compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals.

  咪唑喹啉化合物、其盐、共轭物、含有该化合物和共轭物的制药组合物，以及将这些化合物用作免疫应答调节剂的方法，用于在人类和动物中诱导细胞因子生物合成。
• Conjugation of biomolecules using diels-alder cycloaddition
  申请人：The Government of the U.S.A. as represented by the Secretary of the Dept. of Hlth. and Human Service

  公开号：US20040082067A1

  公开（公告）日：2004-04-29

  A method is provided for covalently linking carbohydrates, proteins, nucleic acids, and other biomolecules under neutral conditions, using a Diels-Alder cycloaddition reaction. In an example, activated carbon-carbon double bonds were attached to free amino sites of a carrier protein, and a conjugated diene was attached to a carbohydrate hapten. Spontaneous coupling of the carbohydrate and the protein components under very mild conditions provided glycoconjugates containing up to 37 carbohydrate hapten units per carrier protein molecule. The method is also applicable to the immobilization of biomolecules on gel or solid supports. The conjugated products are useful as immunogens and as analytical and diagnostic reagents.

  提供了一种方法，可以在中性条件下利用Diels-Alder环加成反应共价连接碳水化合物、蛋白质、核酸和其他生物分子。例如，活性碳-碳双键被连接到载体蛋白质的游离氨基位点上，而共轭二烯被连接到碳水化合物半抗原上。在非常温和的条件下，碳水化合物和蛋白质组分自发耦合，提供含有每个载体蛋白质分子最多37个碳水化合物半抗原单位的糖蛋白。该方法也适用于将生物分子固定在凝胶或固体支持上。这些共轭产物可用作免疫原和分析和诊断试剂。
• Conjugation of biomolecules using Diels-Alder cycloaddition
  申请人：——

  公开号：US20020051788A1

  公开（公告）日：2002-05-02

  A method is provided for covalently linking carbohydrates, proteins, nucleic acids, and other biomolecules under neutral conditions, using a Diels-Alder cycloaddition reaction. In an example, activated carbon-carbon double bonds were attached to free amino sites of a carrier protein, and a conjugated diene was attached to a carbohydrate hapten. Spontaneous coupling of the carbohydrate and the protein components under very mild conditions provided glycoconjugates containing up to 37 carbohydrate hapten units per carrier protein molecule. The method is also applicable to the immobilization of biomolecules on gel or solid supports. The conjugated products are useful as immunogens and as analytical and diagnostic reagents.

  提供了一种方法，在中性条件下，使用Diels-Alder环加成反应，共价连接碳水化合物、蛋白质、核酸和其他生物分子。在一个例子中，活化的碳-碳双键被连接到载体蛋白质的自由氨基位点上，并将共轭二烯连接到碳水化合物半抗原上。在非常温和的条件下，碳水化合物和蛋白质组分自发耦合，提供了每个载体蛋白质分子最多含有37个碳水化合物半抗原单位的糖蛋白。该方法也适用于在凝胶或固体支持上固定生物分子。共轭产物可用作免疫原和分析和诊断试剂。