3-吡啶基甲烷二醇 | 105868-53-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-吡啶基甲烷二醇
• 英文名称: Pyridin-3-ylmethanediol
• CAS: 105868-53-9
• 化学式: C₆H₇NO₂
• 分子量: 125.127
• InChiKey: CTZBYLVHJHSEPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  53.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  3-吡啶基甲烷二醇 生成 3-吡啶甲醛
  参考文献：
  名称：

  Owen, Terence C., Journal of Heterocyclic Chemistry, 1990, vol. 27, # 4, p. 987 - 990

  摘要：

  DOI：
• 作为产物：
  描述：

  3-吡啶甲醛 以 水 为溶剂， 生成 3-吡啶基甲烷二醇
  参考文献：
  名称：

  甲酰基吡啶和维生素B 6相关化合物中的宝石-二元醇和半缩醛形式：固态NMR和单晶X射线衍射研究

  摘要：

  很少分离或什至在固态下研究有机化合物的宝石二醇部分。在这里，液相和固态NMR以及单晶X射线衍射研究被用来显示不同的策略，有利于宝石-二醇或羰基部分以及分离与甲酰吡啶和维生素B 6相关的半缩醛结构。化合物。吡啶化合物中羰基的位置变化对水合具有明显和直接的影响，而三氟乙酸的加入则增强了水合作用。由于其生物化学重要性，因此研究了维生素B 6相关化合物，重点是阐明宝石。-二醇，环状半缩醛或羰基结构可以在不同的实验条件下获得。尤其是，据报道，吡fluoro醛具有环状半缩醛结构的新外消旋混合物，形式为三氟乙酸盐和盐酸盐衍生物。

  DOI：

  10.1021/acs.jpca.6b07898

文献信息

• [EN] KETONE INHIBITORS OF LYSINE GINGIPAIN<br/>[FR] INHIBITEURS CÉTONE DE LYSINE GINGIPAÏNE
  申请人：CORTEXYME INC

  公开号：WO2018053353A1

  公开（公告）日：2018-03-22

  The present invention provides compounds according to Formula (I) as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

  本发明提供了如下式（I）所述的化合物，以及它们用于抑制牙龈假单胞菌（Porphyromonas gingivalis）的赖氨酸基因底物蛋白酶（Kgp）的用途。还描述了牙龈蛋白酶活性探针化合物和测定牙龈蛋白酶活性的方法，以及用于治疗与牙龈假单胞菌感染相关的疾病的方法，包括阿尔茨海默病等脑部疾病。
• [EN] 2-HYDROXYMETHYL-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DES RÉCEPTEURS DE L'OREXINE SUBSTITUÉS PAR UN GROUPE 2-HYDROXYMÉTHYLE
  申请人：MERCK SHARP & DOHME

  公开号：WO2014176144A1

  公开（公告）日：2014-10-30

  The present invention is directed to 2-hydroxymethyl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及对促觉醒素受体拮抗剂的2-羟甲基化合物。本发明还涉及所述化合物在潜在治疗或预防促觉醒素受体参与的神经学和精神疾病和疾病中的用途。本发明还涉及包含这些化合物的药物组合物。本发明还涉及这些药物组合物在预防或治疗促觉醒素受体参与的这类疾病中的用途。
• Antibacterial agents
  申请人：Ellsworth Lee Edmund

  公开号：US20050096278A1

  公开（公告）日：2005-05-05

  Compounds of formula I, II, III, IV, IV, and VI and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

  本文披露了I、II、III、IV、V和VI式化合物的制备方法。还披露了制备公式I的生物活性化合物的方法，以及包括公式I化合物的药学上可接受的组合物的方法。本文所披露的公式I化合物可用于各种应用，包括用作抗菌剂。
• MEMBER FOR ELECTROPHOTOGRAPHY, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP4063675A1

  公开（公告）日：2022-09-28

  An electrophotographic member includes an electro-conductive substrate, and an elastic layer as a surface layer, the elastic layer constituted by a single-layer, wherein the elastic layer includes a first resin, a second resin and an anion, the first resin is a crosslinked urethane resin, and the crosslinked urethane resin is a resin having a specific cationic structure in the molecule, the second resin is at least one of a crosslinked acrylic resin having an ether bond and a crosslinked epoxy resin having an ether bond, and in a first area of the elastic layer, the first are being from an outer surface of the elastic layer to a depth of 0.1 µm, the first resin and the second resin form an interpenetrating polymer network structure.

  一种电子照相构件包括导电基底和作为表层的弹性层，弹性层由单层构成，其中弹性层包括第一树脂、第二树脂和阴离子，第一树脂是交联聚氨酯树脂，交联聚氨酯树脂是分子中具有特定阳离子结构的树脂，第二树脂是具有醚键的交联丙烯酸树脂和交联聚氨酯树脂中的至少一种、交联聚氨酯树脂是分子中具有特定阳离子结构的树脂，第二树脂是具有醚键的交联丙烯酸树脂和具有醚键的交联环氧树脂中的至少一种，在弹性层的第一区域，第一区域是从弹性层的外表面到深度为 0.1 微米，第一树脂和第二树脂形成互穿聚合物网络结构。
• Ketone inhibitors of lysine gingipain
  申请人：CORTEXYME, INC.

  公开号：US10730826B2

  公开（公告）日：2020-08-04

  The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

  本发明提供了根据本文所述式 I 的化合物及其用于抑制牙龈卟啉单胞菌的赖氨酸gingipain蛋白酶（Kgp）的用途。本发明还描述了龈肽酶活性探针化合物和检测龈肽酶活性的方法，以及治疗与牙龈卟啉单胞菌感染有关的疾病（包括阿尔茨海默病等脑部疾病）的方法。