1,2,2,3,3,4,4,6,7,7,8,8,9,9-Tetradecafluoro-5,6-bis(trifluoromethyl)bicyclo[3.3.1]nonane | 75108-51-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: 1,2,2,3,3,4,4,6,7,7,8,8,9,9-Tetradecafluoro-5,6-bis(trifluoromethyl)bicyclo[3.3.1]nonane
• 英文别名: 1,2,2,3,3,4,4,6,7,7,8,8,9,9-tetradecafluoro-5,6-bis(trifluoromethyl)bicyclo[3.3.1]nonane
• CAS: 75108-51-9
• 化学式: C₁₁F₂₀
• 分子量: 512.08
• InChiKey: PCHPLYQGVZMJRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  31
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  20

文献信息

• Perfluorocarbon liquids useful in eye treatment and diagnostic procedures
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：EP0089232A2

  公开（公告）日：1983-09-21

  Perfluorocarbon liquids are disclosed as being useful as substitutes for the vitreous or aqueous of the eye, and as transparentizing agents in the cornea or lens of the eye. Radiopaque liquid perfluorocarbons are useful as radiopaque agents in diagnostic procedures on the eye.

  已公开的全氟化碳液体可用作眼睛玻璃体或水液的替代物，也可用作眼睛角膜或晶状体的透明剂。 不透射线的液态全氟化碳可用作眼睛诊断程序中的不透射线剂。
• Extraocular device for treating the eye
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：EP0112658A2

  公开（公告）日：1984-07-04

  Extraocular ophthalmic preparations or devices useful as therapeutic, diagnostic lubricating or protective agents are disclosed. Perfluorocarbon films or gels are employed extraocularly as contact lenses. Liquid perfluorocarbons and substituted derivatives are the active components of the ophthalmic preparations. The neat perfluorocarbon liquids are not aqueous, wherefore, isotonicity and pH need not be considered in their preparation. Liquid sterility may be maintained without the addition of preservatives. Cornea and conjunctiva surfaces are provided with greater amounts of oxygen when the perfluorcarbon liquids are employed as eye drops. Transparent contact lenses having oxygen permeable properties are provided by the extraocular perfluorocarbon films or discs. Emulsions of perfluorocarbons in water are also suitable for all of the above uses and as carriers for drugs, antibiotics, hormones and therapeutic agents.

  公开了可用作治疗、诊断润滑剂或保护剂的眼外眼科制剂或装置。全氟碳薄膜或凝胶可用作眼外隐形眼镜。液态全氟化碳和取代衍生物是眼科制剂的活性成分。纯净的全氟化碳液体不是水溶液，因此在制备过程中无需考虑等渗性和 pH 值。无需添加防腐剂即可保持液体无菌。当全氟碳化物液体用作滴眼液时，角膜和结膜表面可获得更多的氧气。眼外全氟碳化合物薄膜或圆片可提供具有透氧特性的透明隐形眼镜。全氟碳化合物在水中的乳化液也适用于上述所有用途，并可作为药物、抗生素、激素和治疗剂的载体。
• Method of detecting temperature in an object
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：EP0122000A2

  公开（公告）日：1984-10-17

  A method to detect indirectly a temperature of an object employing nuclear magnetic resonance techniques (NMR). The method involves obtaining an NMR spectrum to determine chemical shift, relaxation times, spin-spin couplings or quadrupole couplings for an element of a compound having at least one conformational isomer wherein the compound is influenced by a temperature of the object. The difference between the detected radio frequency signals for the same element, spectral patterns or chemical shifts corresponds to the temperature of the object.

  一种利用核磁共振技术间接检测物体温度的方法。该方法包括获取核磁共振谱，以确定具有至少一种构象异构体的化合物中某一元素的化学位移、弛豫时间、自旋-自旋耦合或四极耦合，其中该化合物受物体温度的影响。 检测到的同一元素的射频信号、光谱模式或化学位移之间的差异与物体的温度相对应。
• Liquid perfluorocarbons, for use in ocular therapy, and preparations containing them
  申请人：Haidt, Sterling Joel

  公开号：EP0089815B1

  公开（公告）日：1986-12-17
• DRUG DELIVERY VEHICLES SUSPENDED IN NONAQUEOUS PERFLUORINATED CARRIER
  申请人：ALLERGAN, INC.

  公开号：EP0550615B1

  公开（公告）日：1995-08-02