1-[(Cyclooctanecarbonyl)oxy]pyrrolidine-2,5-dione | 61274-15-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-[(Cyclooctanecarbonyl)oxy]pyrrolidine-2,5-dione
• 英文别名: (2,5-dioxopyrrolidin-1-yl) cyclooctanecarboxylate
• CAS: 61274-15-5
• 化学式: C₁₃H₁₉NO₄
• 分子量: 253.29
• InChiKey: BLMYVMVAJSBAQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• CATIONIC NANOSTRUCTURES FOR INTRA-CARTILAGE DELIVERY OF THERAPEUTICS AND CONTRAST AGENTS
  申请人：Northeastern University

  公开号：US20210154307A1

  公开（公告）日：2021-05-27

  The present invention provides a platform for the delivery of small molecule drugs or contrast agents to joints and other soft tissues. The platform enables penetration of the drug through the full thickness of cartilage and long intra-cartilage residence time by leveraging electrostatic interactions between the cationic platform and the anionic cartilage matrix. Described herein are compounds and complexes that fit this platform. Also provided are methods of treating a joint disease with the compounds and complexes of the invention, and methods of imaging joints and other soft tissue.

  本发明提供了一种将小分子药物或造影剂输送到关节和其他软组织的平台。该平台通过利用阳离子平台与阴离子软骨基质之间的静电相互作用，使药物穿透软骨的全部厚度，并具有长时间的软骨内滞留时间。本发明描述了符合该平台的化合物和复合物。还提供了使用本发明中的化合物和复合物治疗关节疾病的方法，以及成像关节和其他软组织的方法。
• ORGANOMETALLIC LABELS FOR THE DETECTION OF BIOMOLECULES, METHODS OF SYNTHESIS AND PROCESSES FOR CONJUGATING AN ORGANOMETALLIC LABELS TO A BIOMOLECULE
  申请人：George Mason Research Foundation, Inc.

  公开号：US20210231652A1

  公开（公告）日：2021-07-29

  A labeling molecule is provided. The labeling molecule includes a compound of the following formula: CA-(M)-A]n. In the formula, “A” is a label anchor moiety, “M” is an identification moiety, and “CA” is a coordination agent moiety. The label anchor is an organic moiety that binds to a surface of a targeted biomolecule through noncovalent or covalent interactions at one end of the label anchor and binds a coordination moiety. The coordination moiety includes an identification moiety at an end that is distal to the end conjugated to the surface of the targeted biomolecule, and the subscript “n” is 1, 2, 3, 4, or 5.
• FLUORESCENT WATER TREATMENT COMPOUNDS AND METHOD OF USE
  申请人：ChampionX USA Inc.

  公开号：US20220024788A1

  公开（公告）日：2022-01-27

  Disclosed herein are graphene quantum dot tagged water source treatment compounds or polymers, and methods of making and using. Also described herein are tagged compositions including an industrial water source treatment compound or polymer combined with a graphene quantum dot tagged water source treatment compound or polymer. The tagged materials are tailored to fluoresce at wavelengths with minimized correspondence to the natural or “background” fluorescence of irradiated materials in industrial water sources, enabling quantification of the concentration of the water source treatment compound or polymer in situ by irradiation and fluorescence measurement of the water source containing the tagged water source treatment compound or polymer. The fluorescence measurement methods are similarly useful to quantify mixtures of tagged and untagged water source treatment compounds or polymers present in an industrial water source.
• [EN] GRANZYME B DETECTION<br/>[FR] DÉTECTION DE LA GRANZYME B
  申请人：[en]THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH

  公开号：WO2022258997A1

  公开（公告）日：2022-12-15

  The present disclosure relates to the development of novel cleavable peptide probes for use in detecting granzyme B, as well as methods for using the probes in medical and biological settings. The probes may comprise a fluorescent moiety conjugated or bound to the peptide, and quencher moiety conjugated or bound to the peptide and upon cleavage of the peptide, the fluorescent moiety becomes dequenched.