3-氟-2-碘苯甲醛 | 905808-02-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-氟-2-碘苯甲醛
• 英文名称: 3-Fluoro-2-iodobenzaldehyde
• CAS: 905808-02-8
• 化学式: C₇H₄FIO
• 分子量: 250.01
• InChiKey: UOGQXTVHJKVPLF-UHFFFAOYSA-N

物化性质

• 沸点：
  262.3±25.0℃ (760 Torr)
• 密度：
  1.962±0.06 g/cm3 (20 ºC 760 Torr)
• 闪点：
  112.4±23.2℃

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

文献信息

• [EN] MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES<br/>[FR] DÉRIVÉS MACROCYCLIQUES POUR LE TRAITEMENT DE MALADIES PROLIFÉRATIVES
  申请人：PFIZER

  公开号：WO2013132376A1

  公开（公告）日：2013-09-12

  The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

  该发明涉及本文进一步定义的Φ式化合物及其药用盐，包括含有这些化合物和盐的药物组合物，以及它们的用途。本发明的化合物和盐抑制间变性淋巴瘤激酶（ALK）和/或EML4-ALK，并且适用于治疗或改善异常细胞增殖性疾病，如癌症。
• N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS
  申请人：Konradi Andrei W.

  公开号：US20100081680A1

  公开（公告）日：2010-04-01

  The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4: wherein the A-ring, B-ring, C-ring, m, n, R 25 , R 50 , and R 51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae 1, 2, 3, and 4, as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae 1, 2, 3, and 4.

  当前发明提供具有根据公式1、2、3和4结构的化合物：其中A环、B环、C环、m、n、R25、R50和R51如说明书所述。该发明还提供了包含公式1、2、3和4化合物的药物组合物，以及治疗认知障碍的方法，如阿尔茨海默病。该发明进一步提供了用于制备公式1、2、3和4化合物的有用的中间体。
• BISAMID-ZINKBASEN
  申请人：Knochel Paul

  公开号：US20100160632A1

  公开（公告）日：2010-06-24

  The present invention relates to zinc amide bases of the general formula (I) (R 1 R 2 N) 2 —Zn. a MgX 1 2 .b LiX 2 (I) wherein R 1 and R 2 are each independently selected from substituted or unsubstituted, linear or branched alkyl, alkenyl, alkynyl or silyl derivatives thereof, and substituted or unsubstituted aryl or heteroaryl, and wherein R 1 and R 2 can form together a ring structure, or R 1 and/or R 2 can be part of a polymer structure; X 1 2 is a divalent anion or two monovalent anions that are independent from each other; X 2 is a monovalent anion; a is >0; and b is >0. The zinc amide bases can be used, amongst other things, for deprotonation and metallization of aromatics.

  本发明涉及一般式(I)(R1R2N)2—Zn.aMgX12.bLiX2的锌酰胺碱，其中R1和R2均独立地选择其取代或未取代的线性或支链烷基，烯基，炔基或其硅基衍生物，以及取代或未取代的芳基或杂环芳基，其中R1和R2可以一起形成环状结构，或者R1和/或R2可以是聚合物结构的一部分；X12是二价阴离子或两个彼此独立的单价阴离子；X2是单价阴离子；a>0；b>0。锌酰胺碱可以用于芳香族物质的去质子化和金属化等方面。
• MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF DISEASES
  申请人：PFIZER INC.

  公开号：US20130252961A1

  公开（公告）日：2013-09-26

  The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

  本发明涉及公式（Φ）的化合物，如此处进一步定义的，并涉及其药学上可接受的盐，包括含有这种化合物和盐的制药组合物，以及其用途。本发明的化合物和盐抑制无形淋巴瘤激酶（ALK）和/或EML4-ALK，并可用于治疗或改善异常细胞增殖性疾病，如癌症。
• MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES
  申请人：Pfizer Inc.

  公开号：EP2822953B1

  公开（公告）日：2017-02-01