3-氨基-1,1-二乙基脲 | 80894-32-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3-氨基-1,1-二乙基脲
• 英文名称: 4,4-diethylsemicarbazide
• 英文别名: diethyl semicarbazide；4,4-diethyl semicarbazide；4,4-Diaethyl-semicarbazid；3-amino-1,1-diethylurea
• CAS: 80894-32-2
• 化学式: C₅H₁₃N₃O
• 分子量: 131.178
• InChiKey: MYLMZXNDVMFRBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-氨基-1,1-二乙基脲 生成 3-[(E)-benzylideneamino]-1,1-diethylurea
  参考文献：
  名称：

  DAVIDSON, J. S., MONATSH. CHEM., 1984, 115, N 5, 565-571

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N-二乙基氯甲酰胺 在 一水合肼 作用下， 以 乙醚 、 乙醇 为溶剂， 以592 mg (33%)的产率得到3-氨基-1,1-二乙基脲
  参考文献：
  名称：

  Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof

  摘要：

  这项发明涉及由式I表示的含有碳环和杂环取代的半卡巴松和硫代半卡巴松： 1 或其药学上可接受的盐或前药，其中： Y为氧或硫；R 1 ，R 21 ，R 22 和R 23 独立地为氢，烷基，环烷基，烯基，炔基，卤代烷基，芳基，氨基烷基，羟基烷基，烷氧基烷基或羧基烷基；或R 22 和R 23 ，与N一起形成一个杂环；A 1 和A 2 独立地为芳基，杂芳基，饱和或部分不饱和的碳环或饱和或部分不饱和的杂环，其中任何一个可选择地被取代；X为O、S、NR 24 、CR 25 R 26 、C(O)、NR 24 C(O)、C(O)NR 24 、SO、SO 2 或共价键；其中R 24 ，R 25 和R 26 独立地为氢，烷基，环烷基，烯基，炔基，卤代烷基，芳基，氨基烷基，羟基烷基，烷氧基烷基或羧基烷基。该发明还涉及利用含有碳环和杂环取代的半卡巴松和硫代半卡巴松治疗全脑和局部缺血后的神经损伤，治疗或预防神经退行性疾病如肌萎缩侧索硬化症（ALS），治疗和预防耳神经毒性和涉及谷氨酸毒性的眼病，以及治疗、预防或改善疼痛，作为抗癫痫药，作为抗躁狂抑郁药，作为局部麻醉药，作为抗心律失常药，以及治疗或预防糖尿病性神经病变和尿失禁。

  公开号：

  US20020061886A1

文献信息

• Storage and Clutter: Discourses and Practices of Order in the Domestic World
  作者：S. B. Cwerner、A. Metcalfe

  DOI：10.1093/jdh/16.3.229

  日期：2003.1.1

  This article examines discourses and practices of storage and clutter in relation to the social construction of the home in contemporary Britain. The role of storage practices has been overlooked in much of the literature on consumption, material culture, design and the home. And yet, especially since the 1990s, there has been an explosion in popular cultural forms of discussion and representations of the home while much of this has explored the domestic worlds of design, decoration and DIY more generally, a large number of books have focused specifically on storage as the antidote to what is preceived as the growing problem of clutter in the contemporary home. Through an analysis of these texts we show that even though they wrap up their ideas in a popular psychology of personal therpy, they do provide some insights useful for discussions of issues related to consumption, material culture and domestic design. More fundamentally, they reveal that the home needs to be coceptualized not simply as a place for living, but also as set of spaces, channels and flows, as objects and people find their way into, through, and sometimes out of, the home. We argue that at the heart of these discourses is a limited conceptualization of time and space and a desire to make spaces and objects present and manageable. We then contrast these discourses with everyday practices of storage and clutter in the home. Based on original research data, we argue that time and space need to be analysed as multiple and layered, as objects are subject to various practices of dispersal, divestment and displacement in the gaps between consumption as acquisition, use and their eventual disposal. As a result, clutter needs to be understood not merely as the underside of storage, but also as part of an iterative spatio-temporal ordering of home and identity that follows the traces left behind by the dynamic of storage.

  本文探讨了与当代英国家居社会建设有关的存储和杂乱的论述与实践。在许多关于消费、物质文化、设计和家居的文献中，存储实践的作用一直被忽视。然而，特别是自 20 世纪 90 年代以来，关于家居的流行文化讨论和表现形式出现了爆炸式的增长，其中大部分探讨了更广泛的设计、装饰和 DIY 等家居世界，而大量书籍则特别关注储藏，将其视为解决当代家居中日益严重的杂乱问题的解药。通过对这些书籍的分析，我们发现，尽管这些书籍将其观点包装成了一种流行的个人心理，但它们确实为讨论与消费、物质文化和家居设计相关的问题提供了一些有用的见解。更重要的是，它们揭示了家居不仅需要被视为一个居住场所，还需要被视为一系列空间、通道和流动，因为物品和人都会进入、通过家居，有时还会离开家居。我们认为，这些论述的核心是对时间和空间的有限概念化，以及让空间和物品呈现出来并便于管理的愿望。然后，我们将这些论述与家庭中的日常存储和杂乱做法进行对比。基于原始研究数据，我们认为时间和空间需要作为多重和多层次来分析，因为物品在消费、获取、使用和最终处置之间的空隙中，会受到各种分散、剥离和移位做法的影响。因此，凌乱不仅需要被理解为储藏的背面，还需要被理解为家庭和身份的迭代时空排序的一部分，这种排序遵循储藏动态留下的痕迹。
• Synthesis, properties, and application of 4-nitrosemicarbazones
  作者：V. S. Glukhacheva、S. G. Il’yasov、G. V. Sakovich、T. G. Tolstikova、A. O. Bryzgalov、N. V. Pleshkova

  DOI：10.1007/s11172-016-1336-9

  日期：2016.2

  approach to the synthesis of N-nitrosemicarbazones, promising high-energy and biologically active compounds. Subsequent treatment with amines and alkalis led to the synthesis of water-soluble salts of nitrosemicarbazones, as well as the corresponding semicarbazones. The reaction of N,N′-diisopropyl- or N,N′-di-tert-butyl-1,2-ethanediimine with 4-nitrosemicarbazide led to the synthesis of glyoxal bis

  4-亚硝基氨基脲 (4-NSC) 与各种醛和酮缩合的研究导致开发了一种合成 N-亚硝基氨基脲的方法，这是一种有前途的高能量和生物活性化合物。随后用胺和碱处理导致合成亚硝基缩脲的水溶性盐以及相应的缩氨基脲。N,N'-二异丙基-或 N,N'-二叔丁基-1,2-乙二亚胺与 4-亚硝基氨基脲的反应导致合成乙二醛双（亚硝基氨基脲）衍生物。使用 PASS 软件的计算机辅助筛选显示所获得的化合物可能具有高生物活性，而樟脑亚硝基缩脲钾盐的抗心律失常特性在大鼠实验中得到证实。
• Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?
  作者：Kim K. Adkison、David G. Barrett、David N. Deaton、Robert T. Gampe、Anne M. Hassell、Stacey T. Long、Robert B. McFadyen、Aaron B. Miller、Larry R. Miller、J. Alan Payne、Lisa M. Shewchuk、Kevin J. Wells-Knecht、Derril H. Willard、Lois L. Wright

  DOI：10.1016/j.bmcl.2005.10.108

  日期：2006.2

  Starting from potent aldehyde inhibitors with poor drug properties, derivatization to semicarbazones led to the identification of a series of semicarbazone-based cathepsin K inhibitors with greater solubility and better pharmacokinetic profiles than their parent aldehydes. Furthermore, a representative semicarbazone inhibitor attenuated bone resorption in an ex vivo rat calvarial bone resorption model. However, based on enzyme inhibition comparisons at neutral pH, semicarbazone hydrolysis rates, and 13C NMR experiments, these semicarbazones probably function as prodrugs of aldehydes.
• The preparation of 5-(2-aminophenyl)-1,3,4-oxadiazole-2(3H)-one and its rearrangement to 3-amino-2,4(1H,3H)-quinazolinedione
  作者：John S. Davidson

  DOI：10.1007/bf00799164

  日期：1984.5