3-氨基-1-苯基丙烷-1-醇 | 7505-01-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3-氨基-1-苯基丙烷-1-醇
• 英文名称: 3-Amino-1-phenylpropan-1-ol hydrochloride
• 英文别名: 3-amino-1-phenylpropan-1-ol;hydrochloride
• CAS: 7505-01-3
• 化学式: C9H14ClNO
• 分子量: 187.66
• InChiKey: GWAJWRXFIVOHTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.49
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.2
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• Manufacture of hollow fine tubular drug delivery systems
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0257560A1

  公开（公告）日：1988-03-02

  A process for preparing a hollow tube drug delivery system comprises : a. extruding a polymer solution or suspension through an annular orifice to provide a tubular membrane having a hollow core; b. simultaneously extruding a drug suspended in a polymer solution into the hollow core of the tubular membrane to provide a drug encapsulated tubular membrane system; c. passing the system into a non-solvent for the polymers having a density different from that of the system, to coagulate the polymers under conditions to minimize orientation in the tube polymer and to create pores in the tube polymer wall; d. removing residual solvent from the system; and e. collecting a drug encapsulated, porous polymeric hollow tube. The resulting system is used for coontrolled release of the encapsulated drug, and more particularly for release of the drug at a constant rate (zero order) for long periods of time.

  一种制备空心管给药系统的工艺包括： a. 通过环形孔挤出聚合物溶液或悬浮液，以提供具有空心的管状膜； b. 同时将悬浮在聚合物溶液中的药物挤入管状膜的中空芯部，形成药物包裹管状膜系统； c. 将系统放入密度与系统密度不同的聚合物非溶剂中，使聚合物凝固，凝固条件是尽量减少管状聚合物的取向，并在管状聚合物壁上形成孔隙； d. 去除系统中的残留溶剂；以及 e. 收集药物包裹的多孔聚合物空心管。 由此产生的系统可用于包封药物的协同控制释放，特别是用于长时间以恒定速率（零阶）释放药物。
• Sugarless pectin delivery system
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0336894A1

  公开（公告）日：1989-10-11

  A sugarless ingestible gel confectionery delivery system which includes a pectin gel component, an algin gel component and a polymer network gel component in amounts sufficient to form a gel confectionery unit. The inventive gel confectionery unit has reduced intrinsic viscosity prior to gelation which permits the inclusion of an edible insoluble solid in an amount sufficient to strengthen the internal combination pectin-algin gel network and to bind internal moisture sufficiently to enhance mold removal capabilities. The delivery system also includes hydrogenated starch hydrolysates. The delivery system may also include a further active ingredient such as a drug, medicament, or nutritional supplement. The product and method of the present invention also includes a composition in which the gel delivery system can be molded directly in the receptacle which is used to dispense the confectionery unti to the consumer.

  一种无糖可食用凝胶糖果输送系统，包括果胶凝胶成分、海藻凝胶成分和聚合物网络凝胶成分，其用量足以形成一个凝胶糖果单元。本发明的凝胶糖果单元在凝胶化之前具有较低的固有粘度，因此可以加入一定量的可食用不溶性固体，以加强内部的果胶-藻胶组合凝胶网络，并充分结合内部水分以提高脱模能力。给料系统还包括氢化淀粉水解物。给药系统还可包括其他活性成分，如药物、药品或营养补充剂。本发明的产品和方法还包括一种组合物，在这种组合物中，凝胶输送系统可以直接在用于将糖果分发给消费者的容器中成型。
• Aqueous film-forming compositions for controlling the release of active agents and process of making same
  申请人：DOW CORNING CORPORATION

  公开号：EP0277740B1

  公开（公告）日：1993-05-19
• FLASH FLOW FORMED SOLLOID DELIVERY SYSTEMS
  申请人：FUISZ TECHNOLOGIES LTD.

  公开号：EP0766514A1

  公开（公告）日：1997-04-09
• EP0766514A4
  申请人：——

  公开号：EP0766514A4

  公开（公告）日：1998-07-01