6-[2-(Propan-2-ylidene)hydrazinyl]pyridine-3-carboxamide | 674369-01-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-[2-(Propan-2-ylidene)hydrazinyl]pyridine-3-carboxamide
• 英文别名: 6-(2-propan-2-ylidenehydrazinyl)pyridine-3-carboxamide
• CAS: 674369-01-8
• 化学式: C₉H₁₂N₄O
• 分子量: 192.22
• InChiKey: DGSDIRKPUMJUJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• POLYCONJUGATES FOR DELIVERY OF RNAI TRIGGERS TO TUMOR CELLS IN VIVO
  申请人：Arrowhead Pharmaceuticals, Inc.

  公开号：EP3030244B1

  公开（公告）日：2021-04-21
• [EN] LIPIDS CAPABLE OF CONFORMATIONAL CHANGE AND THEIR USE IN FORMULATIONS TO DELIVER THERAPEUTIC AGENTS TO CELLS<br/>[FR] LIPIDES POUVANT SUPPORTER UN CHANGEMENT CONFORMATIONNEL ET UTILISATION DE CES DERNIERS DANS DES FORMULATIONS AFIN D'APPORTER DES AGENTS THÉRAPEUTIQUES À DES CELLULES
  申请人：DICERNA PHARMACEUTICALS INC

  公开号：WO2013032643A2

  公开（公告）日：2013-03-07

  The invention provides lipid-based composition for use in the administration of therapeutic payloads to target cells or tissues in vivo. The lipid compounds of the invention include a peptide-based moiety which is induced to change its conformation upon entering a cell or intracellular compartment. The induced conformation change in the peptide-based moiety consequently triggers the efficient release of the payload from the lipid-based composition.