(2S)-2-(4-Iodophenoxy)propanoic acid | 10442-47-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-(4-Iodophenoxy)propanoic acid
• 英文别名: (2S)-2-(4-iodophenoxy)propanoic acid
• CAS: 10442-47-4
• 化学式: C₉H₉IO₃
• mdl: MFCD01764415
• 分子量: 292.07
• InChiKey: ITUIVIPEOVLCML-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compounds For The Treatment Of Neuromuscular Disorders
  申请人：NMD Pharma ApS

  公开号：US20190185409A1

  公开（公告）日：2019-06-20

  The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the ClC-1 ion channel. The compounds include phenoxy propanoic acid, phenoxy propanoate, and phenoxy butanoate compounds.

  本发明涉及适用于治疗、改善和/或预防神经肌肉障碍的化合物，包括逆转药物诱导的神经肌肉阻滞。本说明中定义的化合物优选抑制ClC-1离子通道。这些化合物包括苯氧基丙酸、苯氧基丙酸酯和苯氧基丁酸酯化合物。
• Compounds for the treatment of neuromuscular disorders
  申请人：NMD Pharma ApS

  公开号：US10385028B2

  公开（公告）日：2019-08-20

  The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the CIC-1 ion channel.

  本发明涉及适用于治疗、改善和/或预防神经肌肉疾病的化合物，包括逆转药物诱导的神经肌肉阻滞。本文定义的化合物优选抑制 CIC-1 离子通道。
• Compounds for use in treating neuromuscular disorders
  申请人：NMD PHARMA A/S

  公开号：US10934244B2

  公开（公告）日：2021-03-02

  The present invention relates to compositions comprising compounds for use in treating, ameliorating and/or preventing neuromuscular disorders. The compounds as defined herein preferably inhibit the ClC-1 ion channel. The invention further relates to methods of treating, preventing and/or ameliorating neuromuscular disorders, by administering said composition to a person in need thereof.

  本发明涉及包含用于治疗、改善和/或预防神经肌肉疾病的化合物的组合物。本文定义的化合物优选抑制 ClC-1 离子通道。本发明进一步涉及治疗、预防和/或改善神经肌肉疾病的方法，方法是将所述组合物施用给有需要的人。
• COMPOUNDS FOR USE IN TREATING NEUROMUSCULAR DISORDERS
  申请人：NMD PHARMA APS

  公开号：US20180099920A1

  公开（公告）日：2018-04-12

  The present invention relates to compositions comprising compounds for use in treating, ameliorating and/or preventing neuromuscular disorders. The compounds as defined herein preferably inhibit the ClC-1 ion channel. The invention further relates to methods of treating, preventing and/or ameliorating neuromuscular disorders, by administering said composition to a person in need thereof.