(S)-5-(2,5-Dimethoxy-benzyl)-6-methyl-3,6-dihydro-2H-pyran | 192374-83-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-5-(2,5-Dimethoxy-benzyl)-6-methyl-3,6-dihydro-2H-pyran
• 英文别名: (6S)-5-[(2,5-dimethoxyphenyl)methyl]-6-methyl-3,6-dihydro-2H-pyran
• CAS: 192374-83-7
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: MGGSXRNPENXFNS-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2S,3S,6R)-3-(2,5-Dimethoxy-benzyl)-6-methoxy-2-methyl-3,6-dihydro-2H-pyran-3-ol 在 lithium aluminium tetrahydride 作用下， 以 1,4-二氧六环 为溶剂， 反应 72.0h， 以9%的产率得到(2S,3R)-3-(2,5-Dimethoxy-benzyl)-2-methyl-3,4-dihydro-2H-pyran-3-ol
  参考文献：
  名称：

  Reductive rearrangement of 4-C-substituted hex-2-enopyranosides. Synthesis of 3-deoxy glycals

  摘要：

  4-C-Substituted alpha-erythro and beta-threo hex-2-enopyranosides i.e. with the 4-OH and 1-OMe groups cis, in contrast to their hens stereoisomers, are cleanly reduced by Lithium aluminum hydride to the respective 3-deoxy glycals. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)01001-0

文献信息

• Reductive rearrangement of 4-C-substituted hex-2-enopyranosides. Synthesis of 3-deoxy glycals
  作者：Osman Achmatowicz、Barbara Szechner

  DOI：10.1016/s0040-4039(97)01001-0

  日期：1997.6

  4-C-Substituted alpha-erythro and beta-threo hex-2-enopyranosides i.e. with the 4-OH and 1-OMe groups cis, in contrast to their hens stereoisomers, are cleanly reduced by Lithium aluminum hydride to the respective 3-deoxy glycals. (C) 1997 Published by Elsevier Science Ltd.