3-氨基-5-甲氧基吡啶甲酸 | 1393585-04-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-氨基-5-甲氧基吡啶甲酸
• 英文名称: 3-Amino-5-methoxypicolinic acid
• 英文别名: 3-amino-5-methoxypyridine-2-carboxylic acid
• CAS: 1393585-04-0
• 化学式: C₇H₈N₂O₃
• 分子量: 168.15
• InChiKey: QYEALFALWSJVIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  85.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] IDENTIFICATION AND USE OF ERK5 INHIBITORS<br/>[FR] IDENTIFICATION ET UTILISATION D'INHIBITEURS D'ERK5
  申请人：BAYER AG

  公开号：WO2019170543A1

  公开（公告）日：2019-09-12

  The present invention covers heterocyclic compounds of general formula (I) in which T, U, Y, Z, R1 and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer disorders, as a sole agent or in combination with other active ingredients.

  本发明涵盖了一般式(I)的杂环化合物，其中T、U、Y、Z、R1和R3如本文所定义，制备所述化合物的方法，用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合物，以及利用所述化合物制造用于治疗或预防疾病，特别是癌症疾病的药物组合物的用途，作为唯一活性成分或与其他活性成分组合使用。
• IDENTIFICATION AND USE OF ERK5 INHIBITORS
  申请人：Bayer Aktiengesellschaft

  公开号：EP3762379A1

  公开（公告）日：2021-01-13
• IDENTIFICATION AND USE OF ERK5 INHIBITOR
  申请人：Bayer Aktiengesellschaft

  公开号：US20210017174A1

  公开（公告）日：2021-01-21

  The present invention covers heterocyclic compounds of general formula (I) in which T, U, Y, Z, R1 and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer disorders, as a sole agent or in combination with other active ingredients.