Benzoic acid;5-hydroxy-2-(hydroxymethyl)pyran-4-one | 123377-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzoic acid;5-hydroxy-2-(hydroxymethyl)pyran-4-one
• 英文别名: benzoic acid;5-hydroxy-2-(hydroxymethyl)pyran-4-one
• CAS: 123377-45-7
• 化学式: C13H12O6
• 分子量: 264.23
• InChiKey: GKZVNZHQBBLZNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.22
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] A MELANOGENESIS INHIBITOR COMPOSITION<br/>[FR] COMPOSITION INHIBITRICE DE LA MÉLANOGENÈSE
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2019005437A1

  公开（公告）日：2019-01-03

  A melanogenesis inhibitor combination is provided, comprising: a combination of (Z)-N-(4-hydroxybenzylidene)propan-2-amine oxide; and a compound of formula (I) wherein R1 and R2 are independently selected from a hydrogen atom and an acyl group having 3 to 20 carbon atoms; wherein the combination is dispersed in a dermatologically acceptable carrier.

  提供一种黑色素生成抑制剂组合物，包括：（Z）-N-（4-羟基苄基）丙烯醛胺氧化物的组合物；以及式（I）中的化合物，其中R1和R2分别选自氢原子和具有3到20个碳原子的酰基团；其中该组合物分散在皮肤学上可接受的载体中。
• TOPICAL AGENT FOR DERMATOLOGICAL USE
  申请人：Nakayama Hiroki

  公开号：US20110014141A1

  公开（公告）日：2011-01-20

  The objective of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe and stable topical agents for dermatological use. For that purpose 4-Hydroxyphenyl-α-D-glucopyranoside was combined with auxiliary agents such as ascorbic acid and its derivatives, crude drugs and its extracts, hydroxycarboxylic acid and its salts, oil soluble glycyrrhiza extract, gentian extract, phenol derivatives and their salts, placenta extract, kojic acid and its derivatives, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxin and its derivatives, tocopherol and its derivatives, chitosan and its decomposition products, caffeic acid derivatives, hydroxycinnamate and its derivatives, Umbelliferae plant extracts, mycelial cultures and their extracts, plant leaves and their extracts.

  本发明的目的是增强皮肤美白效果和黑色素生成的预防效果，并提供安全稳定的用于皮肤科的局部制剂。为此，4-羟基苯基-α-D-葡萄糖苷与辅助剂如抗坏血酸及其衍生物、天然药物及其提取物、羟基羧酸及其盐、油溶性甘草提取物、龙胆提取物、酚类衍生物及其盐、胎盘提取物、曲酸及其衍生物、葡萄糖胺及其衍生物、癸二酸及其衍生物、视黄醇及其衍生物、吡哆醇及其衍生物、生育酚及其衍生物、壳聚糖及其分解产物、咖啡酸衍生物、羟基肉桂酸及其衍生物、伞形科植物提取物、菌丝培养物及其提取物、植物叶片及其提取物相结合。
• Whitening cosmetic composition
  申请人：Sansho Seiyaku Co., Ltd.

  公开号：EP0208799A1

  公开（公告）日：1987-01-21

  Placenta extracts and kojic acid or kojic acid derivatives are formulated into cosmetic bases to make cosmetic compositions. The whitening cosmetic compositions exhibit an enhanced whitening effect for the skin by synergestic effects of the placenta extract and kojic acid or kojic acid derivatives.

  将胎盘提取物和曲酸或曲酸衍生物配制成化妆品基料，制成化妆品组合物。通过胎盘提取物和曲酸或曲酸衍生物的协同作用，美白化妆品组合物能增强皮肤的美白效果。
• Compositions for external application
  申请人：Sansho Seiyaku Co., Ltd.

  公开号：EP0308543A1

  公开（公告）日：1989-03-29

  A composition for external application comprising kojic acid or a kojic acid derivative is characterized by formulating 4-(1,1-dimethylethyl) -4′-­methoxydibenzoylmethane therein. The composition has improved effects of inhibiting formation of erythema and pigmentation caused by ultraviolet rays and preventing stains or freckles due to sunburn and having prevented coloration upon use and is an excellent composition for external application such as cosmetics, topical skin agents, etc.

  一种含有曲酸或曲酸衍生物的外用组合物，其特征在于其中配制了 4-(1,1-二甲基乙基) -4′-甲氧基二苯甲酰甲烷。该组合物在抑制紫外线引起的红斑和色素沉着的形成、防止晒伤引起的色斑或雀斑、防止使用时着色等方面具有更好的效果，是化妆品、皮肤外用制剂等外用产品的优良组合物。
• Compositions for topical use having melanin synthesis-inhibiting activity
  申请人：Sansho Seiyaku Co., Ltd.

  公开号：EP0308918A1

  公开（公告）日：1989-03-29

  Compositions for topical use having melanin synthesis-inhibiting activity comprising kojic acid or its esters and vitamin C or its derivatives. The compositions have excellent human skin-whitening effect and anti-suntan effect.

  具有黑色素合成抑制活性的外用组合物，由曲酸或其酯类和维生素 C 或其衍生物组成。这些复合物具有极佳的人体皮肤美白效果和抗褐斑效果。