Triphenyl[(pyridazin-3-yl)methyl]phosphanium chloride | 91438-79-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Triphenyl[(pyridazin-3-yl)methyl]phosphanium chloride
• 英文别名: triphenyl(pyridazin-3-ylmethyl)phosphanium;chloride
• CAS: 91438-79-8
• 化学式: C23H20ClN2P
• 分子量: 390.8
• InChiKey: WSDFMWMOPWXVAO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.97
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Cyclosporins Modified on the MeBmt Sidechain by Heterocyclic Rings
  申请人：Allergan, Inc.

  公开号：US20160289271A1

  公开（公告）日：2016-10-06

  The present invention relates to novel cyclosporin analogs, processes for preparing them, pharmaceutical compositions containing them, and methods for using these analogs and the compositions containing them for the treatment of medical conditions, including but not limited to ocular conditions such as dry eye.

  本发明涉及新型环孢素类似物，制备它们的方法，含有它们的药物组合物，以及利用这些类似物和含有它们的组合物治疗医疗状况的方法，包括但不限于眼部状况如干眼症。
• Cyclosporins modified on the MeBmt sidechain by heterocyclic rings
  申请人：Allergan, Inc.

  公开号：US10077289B2

  公开（公告）日：2018-09-18

  The present invention relates to novel cyclosporin analogs, processes for preparing them, pharmaceutical compositions containing them, and methods for using these analogs and the compositions containing them for the treatment of medical conditions, including but not limited to ocular conditions such as dry eye.

  本发明涉及新型环孢素类似物、制备环孢素类似物的工艺、含有环孢素类似物的药物组合物，以及使用这些类似物和含有环孢素类似物的组合物治疗疾病（包括但不限于干眼症等眼部疾病）的方法。
• CYCLOSPORINS MODIFIED ON THE MEBMT SIDECHAIN BY HETEROCYCLIC RINGS
  申请人：ALLERGAN, INC.

  公开号：EP3277704A1

  公开（公告）日：2018-02-07
• [EN] CYCLOSPORINS MODIFIED ON THE MEBMT SIDECHAIN BY HETEROCYCLIC RINGS<br/>[FR] CYCLOSPORINES MODIFIÉES SUR LA CHAÎNE LATÉRALE MEBMT PAR DES ANNEAUX HÉTÉROCYCLIQUES
  申请人：ALLERGAN INC

  公开号：WO2016160362A1

  公开（公告）日：2016-10-06

  The present invention relates to novel cyclosporin analogs, processes for preparing them, pharmaceutical compositions containing them, and methods for using these analogs and the compositions containing them for the treatment of medical conditions, including but not limited to ocular conditions such as dry eye.