5-(Butan-2-yl)-1,3-thiazolidine-2,4-dione | 89295-67-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-(Butan-2-yl)-1,3-thiazolidine-2,4-dione
• 英文别名: 5-butan-2-yl-1,3-thiazolidine-2,4-dione
• CAS: 89295-67-0
• 化学式: C₇H₁₁NO₂S
• 分子量: 173.24
• InChiKey: DQWXIXQFDILSFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Cystathionine-gamma-lyase (CSE) inhibitors
  申请人：Sova Pharmaceuticals, Inc.

  公开号：US10227314B2

  公开（公告）日：2019-03-12

  Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine-γ-lyase (CSE). Also described herein are methods for using such CSE inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from CSE inhibition.

  本文描述了抑制胱硫醚-γ-赖氨酸酶（CSE）的化合物和含有此类化合物的药物组合物。本文还描述了使用此类 CSE 抑制剂（单独使用或与其他化合物联合使用）治疗可从 CSE 抑制中获益的疾病或病症的方法。
• 2-oxindole compounds
  申请人：CHEMOCENTRYX, INC.

  公开号：US10759789B2

  公开（公告）日：2020-09-01

  Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.

  提供了可用于治疗 CCR(9) 介导的病症或疾病的吲哚化合物。
• SUBSTITUTED 5-AMINOTHIENO[2,3-C]PYRIDAZINE-6-CARBOXAMIDE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
  申请人：Vanderbilt University

  公开号：US20170022216A1

  公开（公告）日：2017-01-26

  In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• CYSTATHIONINE-GAMMA-LYASE (CSE) INHIBITORS
  申请人：Sova Pharmaceuticals, Inc.

  公开号：US20170334866A1

  公开（公告）日：2017-11-23

  Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine-γ-lyase (CSE). Also described herein are methods for using such CSE inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from CSE inhibition.
• 2-OXINDOLE COMPOUNDS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20200123136A1

  公开（公告）日：2020-04-23

  Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.