Furan-3-yl-carbamic acid benzyl ester | 499202-76-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Furan-3-yl-carbamic acid benzyl ester
• 英文别名: Benzyl furan-3-ylcarbamate；benzyl N-(furan-3-yl)carbamate
• CAS: 499202-76-5
• 化学式: C₁₂H₁₁NO₃
• 分子量: 217.224
• InChiKey: HFQJHWVJZLXGEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  51.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2932190090

反应信息

• 作为产物：
  描述：

  3-溴呋喃 、 氨基甲酸苄酯 在 copper(l) iodide 、 potassium carbonate 、 N,N'-二甲基乙二胺 作用下， 反应 24.0h， 以27%的产率得到Furan-3-yl-carbamic acid benzyl ester
  参考文献：
  名称：

  Copper-catalyzed amidations of bromo substituted furans and thiophenes

  摘要：

  The C-N cross-coupling reaction between aromatic halides and amides has now been applied to 2- and 3-substituted bromofurans and bromothiophenes. Catalytic CuI in the presence of N,N'-dimethylethylenediamine as a ligand and K3PO4 or K2CO3 as the base furnished 2- and 3-substituted amidofurans and thiophenes ranging from 11 to 99% depending on the particular amide source used. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)01725-2

文献信息

• Copper-catalyzed amidations of bromo substituted furans and thiophenes
  作者：Kenneth R Crawford、Albert Padwa

  DOI：10.1016/s0040-4039(02)01725-2

  日期：2002.10

  The C-N cross-coupling reaction between aromatic halides and amides has now been applied to 2- and 3-substituted bromofurans and bromothiophenes. Catalytic CuI in the presence of N,N'-dimethylethylenediamine as a ligand and K3PO4 or K2CO3 as the base furnished 2- and 3-substituted amidofurans and thiophenes ranging from 11 to 99% depending on the particular amide source used. (C) 2002 Published by Elsevier Science Ltd.