1a(2)-[1-(3-Azetidinyl)-2,3-dihydro-1H-indol-5-yl]-5-chloro[2,4a(2)-bipyridin]-2a(2)(1a(2)H)-one | 1194732-44-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1a(2)-[1-(3-Azetidinyl)-2,3-dihydro-1H-indol-5-yl]-5-chloro[2,4a(2)-bipyridin]-2a(2)(1a(2)H)-one
• 英文别名: 1-[1-(azetidin-3-yl)-2,3-dihydroindol-5-yl]-4-(5-chloropyridin-2-yl)pyridin-2-one
• CAS: 1194732-44-9
• 化学式: C₂₁H₁₉ClN₄O
• 分子量: 378.9
• InChiKey: SNBFZISWYLNZCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  48.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] AZETIDINE DERIVATIVES<br/>[FR] DÉRIVÉS D'AZÉTIDINE
  申请人：LUNDBECK & CO AS H

  公开号：WO2009137270A2

  公开（公告）日：2009-11-12

  The present invention relates to azetidine derivatives which bind to the MCH l receptor. In separate aspects, the subject invention is directed to uses of said compounds in the preparation of a pharmaceutical composition for the treatment of metabolic and CNS related disorders and to methods of treating said disorders comprising administering a therapeutically effective amount of a compound of the invention.