5-[[3-[(3,5-Dihydroxyphenyl)methoxy]-5-(hydroxymethyl)phenoxy]methyl]benzene-1,3-diol | 156563-27-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5-[[3-[(3,5-Dihydroxyphenyl)methoxy]-5-(hydroxymethyl)phenoxy]methyl]benzene-1,3-diol
• 英文别名: 5-[[3-[(3,5-dihydroxyphenyl)methoxy]-5-(hydroxymethyl)phenoxy]methyl]benzene-1,3-diol
• CAS: 156563-27-8
• 化学式: C₂₁H₂₀O₇
• 分子量: 384.386
• InChiKey: NOYZIRYLUXXZIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  120
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  溴乙酸叔丁酯 、 5-[[3-[(3,5-Dihydroxyphenyl)methoxy]-5-(hydroxymethyl)phenoxy]methyl]benzene-1,3-diol 在 18-冠醚-6 、 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 以80%的产率得到3,5-bis[3',5'-bis(2-(tert-butoxy)-2-oxoethoxy)benzyloxy]benzyl alcohol
  参考文献：
  名称：

  Fluorophore-cored dendrimers for patterns in metalloprotein sensing

  摘要：

  在具有外围结合功能的染料核心树状聚合物中，世代对蛋白质结合诱导的荧光猝灭的影响可能是不可预测的；这是因为随着世代的增加，荧光染料与结合功能的距离增大，同时结合基团的数量也在增加，这两者之间的相互作用被用来创建金属蛋白感应的模式。

  DOI：

  10.1039/b815263b

文献信息

• SUPRAMOLECULAR PROTEIN ASSEMBLIES WITH ADVANCED FUNCTIONS AND SYNTHESIS THEREOF
  申请人：INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH

  公开号：US20190134212A1

  公开（公告）日：2019-05-09

  The present invention discloses stimuli-sensitive protein conjugate which can make supramolecular protein assemblies and methods for using the same. The present invention provides simple and rational process for construction of said stimuli-sensitive spherical protein assemblies through supramolecular chemical strategy.

  本发明公开了一种刺激敏感蛋白共轭物，可以制备超分子蛋白组装体，并提供了使用该共轭物的方法。本发明通过超分子化学策略提供了一种简单而合理的过程，用于构建所述刺激敏感球形蛋白组装体。
• NOVEL SURFACE ACTIVE POLYMERIC SYSTEMS
  申请人：Hutchings Lian Richard

  公开号：US20100036054A1

  公开（公告）日：2010-02-11

  A polymer comprising a bulk polymer or copolymer P B together with an amount of a polymer-dendron additive D-P D of formula (I): is provided, such that the polymer comprises from 0.001 to 50% of dendron-additive D-P D calculated as weight of dendron D in polymers D-P D and P B , wherein: P D is a polymer chain comprising at least one monomer repeat unit and is cyclic (having no ends) or has at least two ends and is linked to group Y in chain or at least one of its ends; Y is a linking group; a and b are each zero or a whole number integer in the range from 1 to 5; A is a branching group; each XZ 1 is a functional group independently selected from one or more of OH, halo, amino, cyano, carboxylic acid, ester, thiol, silane, azide, alkyl, alkenyl, alkynyl, oligoalkyl, oligoalkenyl, oligoalkylether or any organometallic group, a linear, branched or cyclic C 1-20 alkyl, alkenyl or cycloalkyl group optionally comprising a heteroatom O or S and comprising from 3 to 37 functional groups selected from halo, OH, NR 2 , CN, COOH, COOR, SR, SiCl 3 , SiRCl 2 SiR 2 Cl, Si(OR) 3 , and a combination thereof; Z is O or S; is derived as functional groups as hereinbefore defined; G indicates the Generation of a given dendron, in which both a (where present) and b are in the range 1 to 5.

  提供一种聚合物，包括大量聚合物或共聚物PB，以及化学式（I）的聚合物树枝添加剂D-PD的一定量，使得聚合物中包含从0.001％到50％的树枝添加剂D-PD，其计算为聚合物D-PD和PB中树枝D的重量，其中：PD是由至少一个单体重复单元组成的聚合物链，是环状的（没有末端）或至少有两个末端，并与链中的Y基团或其至少一个末端连接；Y是连接基团；a和b分别为0或1至5范围内的整数；A是分支基团；每个XZ1是从OH，卤素，氨基，氰基，羧酸，酯，硫醇，硅烷，叠氮化物，烷基，烯基，炔基，寡烷基，寡烯基，寡烷醚或任何有机金属基团，线性，支链或环状C1-20烷基，烯基或环状基团，可选包含杂原子O或S，并包含来自3至37个卤素，OH，NR2，CN，COOH，COOR，SR，SiCl3，SiRCl2SiR2Cl，Si（OR）3和其组合的功能基团；Z是O或S；派生自如上所定义的功能基团；G表示给定树枝的代数，在其中a（如存在）和b均在1至5的范围内。
• Fluorophore-cored dendrimers for patterns in metalloprotein sensing
  作者：Siriporn Jiwpanich、Britto S. Sandanaraj、S. Thayumanavan

  DOI：10.1039/b815263b

  日期：——

  In fluorophore-cored dendrimers with peripheral binding functionalities, the effect of generation upon protein binding-induced fluorescence quenching can be unpredictable; this is because the increase in fluorophore-binding functionality distance with generation is also accompanied by an increase in the number of binding moieties and the interplay between the two features is utilized to create patterns for metalloprotein sensing.

  在具有外围结合功能的染料核心树状聚合物中，世代对蛋白质结合诱导的荧光猝灭的影响可能是不可预测的；这是因为随着世代的增加，荧光染料与结合功能的距离增大，同时结合基团的数量也在增加，这两者之间的相互作用被用来创建金属蛋白感应的模式。