diclofenac triethanolamine | 80636-43-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diclofenac triethanolamine
• 英文别名: triethanolamine diclofenac salt；Tris(2-hydroxyethyl)ammonium (2,6-dichlorophenyl)amino-phenylacetate (HTEA.D)；2-[2-(2,6-dichloroanilino)phenyl]acetate;tris(2-hydroxyethyl)azanium
• CAS: 80636-43-7
• 化学式: C₆H₁₅NO₃*C₁₄H₁₁Cl₂NO₂
• 分子量: 445.343
• InChiKey: ULRYZADXEBKBBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.63
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  117
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  双氯芬酸 生成 diclofenac triethanolamine
  参考文献：
  名称：

  ECKERT, THEODOR

  摘要：

  DOI：

文献信息

• Topical formulation comprising a NSAID, preferably diclofenac, for alleviating pain/inflammation caused by herpes virus infection
  申请人：Yung Shin Pharm. Ind. Co. Ltd.

  公开号：EP1457202A2

  公开（公告）日：2004-09-15

  The present invention provides a topical formulation containing NSAID, particularly diclofenac. The topical formulation is particularly useful for alleviating pain/inflammation associated with infection caused by herpes virus, especially herpes simplex virus (HSV) and varicella-zoster virus (VZV). Similar relief can be achieved where diclofenac is replaced with another non-steroidal anti-inflammatory drug (NSAID), which includes, without limitation, etodolac, ketorolac, bromfenac, diflunisal, ibuprofen, fenoprofen, ketoprofen, naproxen, suprofen, meclofenamate, mefenamic acid, piroxicam, meloxicam, indomethacin, sulindac, phenylbutazone, oxyphenbutazone, and tolmetin. The topical formulation is further characterized by its fast relief on pain and/or inflammation associated with infection caused by herpes virus, i.e., a complete relief in no more than seven (7) days after the application of the topical formulation on skins of patients.

  本发明提供了一种含有非甾体抗炎药，特别是双氯芬酸的外用制剂。该外用制剂特别适用于缓解与疱疹病毒（尤其是单纯疱疹病毒（HSV）和水痘-带状疱疹病毒（VZV））感染相关的疼痛/炎症。如果用另一种非甾体抗炎药（NSAID）替代双氯芬酸，也可以达到类似的缓解效果，这些药物包括但不限于依托度酸、酮洛拉克、溴芬酸、双氟尼沙、布洛芬酸、双氟利沙、布洛芬酸、布洛芬酸、布洛芬酸、布洛芬酸、布洛芬酸、布洛芬酸、布洛芬酸、布洛芬酸等、双氟尼沙星、布洛芬、非诺洛芬、酮洛芬、萘普生、舒洛芬、甲氯芬那酯、甲芬那酸、吡罗昔康、美洛昔康、吲哚美辛、舒林酸、苯丁酸、氧苯丁酸和托美丁。该外用制剂的另一个特点是能快速缓解与疱疹病毒感染有关的疼痛和/或炎症，即在患者皮肤上使用该外用制剂后不超过七（7）天就能完全缓解疼痛和/或炎症。
• Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection
  申请人：——

  公开号：US20040180066A1

  公开（公告）日：2004-09-16

  The present invention provides a topical formulation containing NSAID, particularly diclofenac. The topical formulation is particularly useful for alleviating pain/inflammation associated with infection caused by herpes virus, especially herpes simplex virus (HSV) and varicella-zoster virus (VZV). Similar relief can be achieved where diclofenac is replaced with another non-steroidal anti-inflammatory drug (NSAID), which includes, without limitation, etodolac, ketorolac, bromfenac, diflunisal, ibuprofen, fenoprofen, ketoprofen, naproxen, suprofen, meclofenamate, mefenamic acid, piroxicam, meloxicam, indomethacin, sulindac, phenylbutazone, oxyphenbutazone, and tolmetin. The topical formulation is further characterized by its fast relief on pain and/or inflammation associated with infection caused by herpes virus, i.e., a complete relief in no more than seven (7) days after the application of the topical formulation on skins of patients.

  本发明提供了一种含有非甾体抗炎药，特别是双氯芬酸的外用制剂。该外用制剂特别适用于缓解与疱疹病毒（尤其是单纯疱疹病毒（HSV）和水痘-带状疱疹病毒（VZV））感染相关的疼痛/炎症。如果用另一种非甾体抗炎药（NSAID）替代双氯芬酸，也能达到类似的缓解效果，这些药物包括但不限于依托度酸、酮洛拉克、溴芬酸、双氟尼沙、布洛芬酸等、双氟尼沙星、布洛芬、非诺洛芬、酮洛芬、萘普生、舒洛芬、甲氯芬那酯、甲芬那酸、吡罗昔康、美洛昔康、吲哚美辛、舒林酸、苯丁酸、氧苯丁酸和托美丁。该外用制剂的进一步特点是能快速缓解与疱疹病毒感染有关的疼痛和/或炎症，即在患者皮肤上涂抹该外用制剂后不超过七（7）天就能完全缓解疼痛和/或炎症。
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  作者：

  DOI：——

  日期：——
• ECKERT, THEODOR
  作者：ECKERT, THEODOR

  DOI：——

  日期：——
• ECKERT, T.
  作者：ECKERT, T.

  DOI：——

  日期：——